中国0~6岁儿童脑瘫患病率的Meta分析  

The Prevalence of Cerebral Palsy in Children Aged 0-6 Years in China:a Meta-analysis

作　　者：封玉霞 庞伟[1,2,3] 李鑫[1,2,3] 杨顺波[1,2] 刘师宇[1,2] 卢淑卿 FENG Yuxia;PANG Wei;LI Xin;YANG Shunbo;LIU Shiyu;LU Shuqing(Rehabilitation Medicine of Jiamusi University,Jiamusi 154003,China;Children Neural Rehabilitation Laboratory of Jiamusi University,Jiamusi 154003,China;The Third Affiliated Hospital of Jiamusi University/Rehabilitation Center for Child Cerebral Palsy of Heilongjiang Province,Jiamusi 154003,China)

机构地区：[1]佳木斯大学康复医学院,黑龙江省佳木斯市154003 [2]佳木斯大学儿童康复神经实验室,黑龙江省佳木斯市154003 [3]佳木斯大学附属第三医院黑龙江省小儿脑瘫防治疗育中心,黑龙江省佳木斯市154003

出　　处：《中国全科医学》2021年第5期603-607,共5页Chinese General Practice

基　　金：黑龙江卫生计生委科研课题(2016-281);黑龙江省教育厅基本科研业务费基础研究项目(2019-KYYWF-1366);佳木斯大学优秀学科团队(JDXKTD-2019006);佳木斯大学科研项目(S2009-042);佳木斯大学校级科技创新团队(Cxtd-2013-02)。

摘　　要：背景脑性瘫痪(以下简称脑瘫)是导致儿童残疾的主要原因之一,同时影响我国人口素质的提高。目前,我国对儿童脑瘫患病率的研究结果差异较大,缺乏基于较大样本量和较新的儿童脑瘫的流行病学研究。目的了解较新的中国0~6岁儿童脑瘫患病情况。方法计算机检索PubMed、Web of Science、The Cochrane Library、中国知网、万方数据知识服务系统、维普网和中国生物医学文献数据库(CBM)发表的关于中国0~6岁儿童脑瘫流行病学研究的文献,检索时限为2015-01-01至2020-01-01。收集纳入文献中调查对象的样本量、调查地区、性别、年龄、患儿例数等信息,并对纳入的文献运用Stata 12.0软件进行Meta分析,对患病率进行定量合并,并对性别、年龄等分类指标进行亚组分析。结果共纳入文献8篇,文献质量均为中等及以上,调查对象共527758例,其中脑瘫患儿1022例。Meta分析结果显示,中国0~6岁儿童脑瘫总患病率为0.23%〔95%CI(0.17%,0.29%)〕;亚组分析结果显示,男童脑瘫患病率为0.22%〔95%CI(0.14%,0.29%)〕,女童脑瘫患病率为0.12%〔95%CI(0.06%,0.19%)〕;<1、1、2、3、4、5、6岁儿童脑瘫患病率分别为0.21%〔95%CI(0.02%,0.40%)〕、0.20%〔95%CI(0.10%,0.30%)〕、0.19%〔95%CI(0.08%,0.30%)〕、0.21%〔95%CI(0.09%,0.32%)〕、0.13%〔95%CI(0.02%,0.24%)〕、0.20%〔95%CI(0.09%,0.32%)〕、0.32%〔95%CI(0.14%,0.50%)〕。结论中国0~6岁儿童脑瘫患病率为0.23%,性别和年龄段的患病率均表现不同,对于政策制定、临床干预有指导意义,建议依据新的脑瘫分型进行更多横断面研究。Background As one of the main causes of children's disability,cerebral palsy(hereinafter referred to as CP)affects the improvement of our population quality.At present,the results of researches on the prevalence of children suffering from CP inour country are quite different,and there is a lack of epidemiological studies based on larger sample sizes and the current prevalence of CP.Objective To learn about the prevalence of CPin children aged 0-6 in China.Methods Literatures on the prevalence of CP in children aged 0-6 in China were retrievaled through computer in PubMed,Web of Science,The Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service System,VIP Database(VIP),and China Biology Medicine disc(CBM),and the publication date limited from January 1st to January 1st,2020.Based on established inclusion criteria,literatures were screened.Meta-analysis was performed on the included literatures with Stata 12.0 software,the prevalence was quantitatively combined,and subgroup analysis was carried out on classification indicators,such as gender and age.Results This study finally included 8 papers of medium or above quality,with a total of 527758 people,including 1022 CP children.The results of Meta-analysis proved that the overall prevalence of CP among children aged 0 to 6 in China was 0.23%〔95%CI(0.17%,0.29%)〕.The subgroup analysis results revealed that the prevalence of boys was 0.22%〔95%CI(0.14%,0.29%)〕,the prevalence of girls was 0.12%〔95%CI(0.06%,0.19%)〕.The prevalence of CP among children at the ages of below one years,one years,two years,three years,four years,five years,and six years was 0.21%〔95%CI(0.02%,0.40%)〕,0.20%〔95%CI(0.10%,0.30%)〕,0.19%〔95%CI(0.08%,0.30%)〕,0.21%〔95%CI(0.09%,0.32%)〕,0.13%〔95%CI(0.02%,0.24%)〕,0.20%〔95%CI(0.09%,0.32%)〕,0.32%〔95%CI(0.14%,0.50%)〕,respectively.Conclusion The prevalence of CP in children aged 0 to 6 in China was 0.23%,and the prevalence of gender and age was different,guiding significance for poli

关 键 词：大脑性瘫痪 儿童 患病率 流行病学 META分析 

分 类 号：R742.3[医药卫生—神经病学与精神病学]