中国胃食管反流病患者焦虑抑郁患病率的Meta分析  

Anxiety and Depression Prevalence in Chinese Patients with Gastroesophageal Reflux Disease:a Meta-analysis

作　　者：周金池 窦维佳 魏延 赵曙光[1] 韩伟[1] 程浩 刘震雄[1] ZHOU Jinchi;DOU Weijia;WEI Yan;ZHAO Shuguang;HAN Wei;CHENG Hao;LIU Zhenxiong(Department of Gastroenterology,Tangdu Hospital,Air Force Medical University,Xi'an 710038,China)

机构地区：[1]中国人民解放军空军军医大学唐都医院消化内科,陕西省西安市710038

出　　处：《中国全科医学》2021年第5期608-613,共6页Chinese General Practice

摘　　要：背景胃食管反流病(GERD)是一种常见的消化系统疾病,在全球呈高发趋势,给患者造成严重的心理负担。GERD与患者的焦虑抑郁密切相关,因此,准确地了解GERD患者的精神状态将有助于更好地进行诊治。但是,目前尚缺乏此方面基于中国人群的系统性分析。目的通过Meta分析的方法系统评价中国GERD患者焦虑抑郁患病情况。方法通过计算机检索中国生物医学文献服务系统、中国知网、万方数据知识服务平台、维普网、PubMed等数据库,检索时间为2000年1月-2020年5月,收集关于中国GERD患者焦虑抑郁患病情况的调查研究。采用Stata 12.0、Revman 5.1软件对焦虑抑郁患病率进行Meta分析。结果共纳入17篇文献,90537例受调查者,文献质量整体较好。Meta分析结果显示,GERD患者焦虑患病率为41%〔95%CI(31%,51%)〕,反流性食管炎(RE)患者焦虑患病率为36%〔95%CI(25%,48%)〕,非糜烂性胃食管反流病(NERD)患者焦虑患病率为51%〔95%CI(44%,58%)〕。GERD患者抑郁患病率为37%〔95%CI(32%,42%)〕,RE患者抑郁患病率为34%〔95%CI(28%,39%)〕,NERD患者抑郁患病率为45%〔95%CI(23%,67%)〕。结论中国人群GERD患者中焦虑抑郁呈高发趋势,GERD患者患焦虑抑郁的风险更大,临床工作中准确地了解GERD患者的精神状况将有助于更好地对GERD患者进行诊疗。Background Gastroesophageal reflux disease(GERD)is a common digestive disease with high global incidence trend,which may cause serious psychological burden on patients,and is closely related to anxiety and depression prevalence in them.Therefore,accurate understanding of the mental state of GERD will contribute to better diagnosis and treatment of GERD.However,there is no systematic analysis of mental status and GERD in Chinese population.Objective To perform a Meta-analysis of studies regarding anxiety and depression prevalence in Chinese GERD patients.Methods Investigative studies on anxiety and depression in Chinese GERD patients published from January 2000 to May 2020 were collected through searching the databases of CBM,CNKI,Wanfang Data,VIP,and PubMed.Meta-analysis was conducted by using Stata 12.0 and Revman 5.1.Results A total of 17 articles involving 90537 subjects were included,with good methodological quality generally.The result showed that the prevalence of anxiety disorder in GERD,reflux esophagitis(RE)and non-erosive reflux disease(NERD)patients was 41%〔95%CI(31%,51%)〕,36%〔95%CI(25%,48%)〕,and 51%〔95%CI(44%,58%)〕,respectively.The prevalence of depression disorder in GERD patients was 37%〔95%CI(32%,42%)〕.The prevalence of depression disorder in depressive disorder in GERD,RE and NERD patients was 37%〔95%C(I 32%,42%)〕,34%〔95%C(I 28%,39%)〕,and 45%〔95%CI(23%,67%)〕,respectively.Conclusion Anxiety and depression presents high prevalence in Chinese GERD patients.As this population is more susceptible to anxiety and depression,understanding their mental status may help to better treat GERD.

关 键 词：胃食管反流 焦虑 抑郁 患病率 流行病学 META分析 

分 类 号：R573.9[医药卫生—消化系统] R749.72[医药卫生—内科学]