基于聚酰胺——胺树枝状聚合物的牙体硬组织仿生再矿化的研究进展  

Research progress on the biomimetic remineralization of hard tooth tissues based on polyamide-amine dendrimer

作　　者：向科臻 陈亮[1] 杨德琴[1] Xiang Kezhen;Chen Liang;Yang Deqin(Oral Hospital Affiliated to Chongqing Medical University,Chongqing Key Laboratory of Oral Diseases and Biomedicine,Key Laboratory of Oral Biomedical Engineering in Chongqing Universities,Chongqing 401147,China)

机构地区：[1]重庆医科大学附属口腔医院/口腔疾病与生物医学重庆市重点实验室/重庆市高校市级口腔生物医学工程重点实验室,重庆401147

出　　处：《华西口腔医学杂志》2020年第6期692-696,共5页West China Journal of Stomatology

基　　金：国家自然科学基金青年基金(8170095);重庆市基础研究与前言探索项目(cstc2018jcyjAX0275)。

摘　　要：聚酰胺—胺树枝状聚合物(PAMAM)作为一种新型超支化大分子聚合物,因其出色的化学和生物学特性,一直被众学者称之为"人工蛋白"。PAMAM的特点是存在内部空腔,并含有大量的反应性末端基团,这些结构使得PAMAM可以被用作仿生大分子,模拟天然有机基质在牙体组织表面进行仿生矿化,即PAMAM作为有机模板调控矿物质成核以及晶体的生长,以此来建造比传统的异体材料更加理想的牙体修复材料。本文就PAMAM诱导牙体硬组织仿生矿化的研究进展作一综述。Polyamide-amine(PAMAM)dendrimer,a new hyperbranched macromolecular polymer,is considered an“artificial protein”by many scholars on account of its excellent chemical and biological characteristics.PAMAM has internal cavities and a large number of reactive terminal groups.These structures allow the polymer to be used as a bionic macromoleculethat could simulate the biomimetic mineralization of the natural organic matrix on the surface of tooth tissue.Specifically,PAMAM can beused as an organic template to regulate mineral nucleation and crystal growth;thus,the polymerisa more ideal dental restoration material than traditional allogenic materials.This article reviews research progress on thePAMAM-induced biomimetic mineralization of hard tooth tissues.

关 键 词：聚酰胺—胺树枝状聚合物 仿生矿化 牙体硬组织 

分 类 号：R780.2[医药卫生—口腔医学]