柴胡四黄汤联合甲硝唑和熊去氧胆酸片治疗慢性胆囊炎的效果及对血清MDA和β-EP水平的影响  

Effects of Chaihu Sihuang decoction combined with metronidazole and ursodeoxycholic acid tablets on chronic cholecystitis and its influence on serum MDA,β-EP

作　　者：王飞[1] 赵迎[1] 刘全忠[2] Wang Fei;Zhao Ying;Liu Quanzhong(Department of Ultrasound,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Department of Spleen Stomach Hepatobiliary,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院超声科,郑州450000 [2]河南中医药大学第一附属医院脾胃肝胆病科,郑州450000

出　　处：《中国实用医刊》2020年第21期116-119,共4页Chinese Journal of Practical Medicine

摘　　要：目的:探究柴胡四黄汤与西药联合治疗慢性胆囊炎的临床价值及安全性,并观察其对患者血清β-内啡肽(β-EP)、丙二醛(MDA)水平的影响。方法:抽取河南中医药大学第一附属医院2018年1月至2019年12月收治的82例慢性胆囊炎患者为研究对象,依据随机数字表法,将入选患者分为中西药组及西药组,每组41例。西药组给予甲硝唑联合熊去氧胆酸片治疗,中西药组在西药组治疗基础上加用柴胡四黄汤治疗。观察两组患者的临床疗效及不良反应发生情况,并比较两组患者治疗前后MAD、β-EP水平。结果:中西药组总有效率(97.56%,40/41)高于西药组(75.61%,31/41),差异有统计学意义(P<0.05)。治疗前,两组β-EP、MAD水平比较差异未见统计学意义(P>0.05);治疗后,两组β-EP、MAD水平均较治疗前下降,且中西药组β-EP、MAD水平低于西药组,差异有统计学意义(P<0.05)。中西药组不良反应发生率为4.88%(2/41),西药组为9.76%(4/41),两组比较差异未见统计学意义(P>0.05)。结论:柴胡四黄汤联合甲硝唑、熊去氧胆酸片治疗慢性胆囊炎具有理想的疗效,能有效抑制患者细胞损伤,维持机体免疫平衡,且不增加不良反应。Objective:To investigate the clinical value and safety of Chaihu Sihuang decoction combined with Western medicine on patients with chronic cholecystitis,and to observe its influence on levels of serumβ-endorphin(β-EP)and malondialdehyde(MDA).Methods:A total of 82 patients with chronic cholecystitis admitted to the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2018 to December 2019 were selected as the research objects.According to the random number table method,all patients were divided into traditional Chinese medicine combined with Western medicine group and Western medicine group,with 41 cases in each group.The patients in Western medicine group were treated with metronidazole combined with ursodeoxycholic acid tablets,and the patients in traditional Chinese medicine combined Western medicine group were treated with Chaihu Sihuang decoction based on the treatment of the Western medicine group.The clinical efficacy and adverse reactions of the two groups were observed,and the levels of MAD andβ-EP were compared between the two groups before and after treatment.Results:The total effective rate of the traditional Chinese medicine combined Western medicine group(97.56%,40/41)was higher than that of the Western medicine group(75.61%,31/41),P<0.05.Before treatment,there was no significant difference in the levels ofβ-EP and MAD between the two groups(P>0.05).After treatment,the levels ofβ-EP and MAD in the two groups were lower than those before treatment,and the levels ofβ-EP and MAD in the traditional Chinese medicine combined Western medicine group were lower than those in the Western medicine group,and the difference was statistically significant(P<0.05).The total adverse reaction rate was 4.88%(2/41)in the traditional Chinese medicine combined Western medicine group,and 9.76%(4/41)in the western medicine group;however,there was no significant difference between the two groups(P>0.05).Conclusions:Chaihu Sihuang decoction combined with metronidazole and ursodeoxy

关 键 词：柴胡四黄汤 慢性胆囊炎 Β-内啡肽 丙二醛 

分 类 号：R575.61[医药卫生—消化系统]