血清Lp-PLA2、MMP-9表达水平与缺血性脑卒中患者血管性痴呆的相关性  

Correlation between serum Lp-PLA2 and MMP-9 expression levels and vascular dementia in patients with acute ischemic stroke

作　　者：宁庆[1] 尹浩军[1] 孙广锋 王斐 NING Qing;YIN Haojun;SUN Guangfeng;WANG Fei(Department of Neurology,Hubei Armed Police Corps Hospital,Wuhan 430061,Hubei,China)

机构地区：[1]武警湖北省总队医院神经内科,湖北武汉430061

出　　处：《中南医学科学杂志》2020年第6期572-575,共4页Medical Science Journal of Central South China

摘　　要：探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)、基质金属蛋白酶-9(MMP-9)水平与缺血性脑卒中(AIS)患者血管性痴呆(VD)相关性。根据109例AIS患者是否发生VD分为血管性痴呆组(n=50)和非血管性痴呆组(n=59)。结果显示,与非血管性痴呆组相比,血管性痴呆组血清Lp-PLA2、MMP-9水平显著升高,且随血管性痴呆严重程度的增加而上升,结果说明,血管性痴呆严重程度与血清Lp-PLA2、MMP-9水平呈正相关,Lp-PLA2、MMP-9有望成为AIS致血管性痴呆的预测指标。To investigate the correlation between serum lipoprotein-associated phospholipase A2(Lp-PLA2)and matrix metalloproteinase-9(MMP-9)expression levels and vascular dementia(VD)in patients with acute ischemic stroke(AIS),109 AIS patients were divided into vascular dementia group(n=50)and non-vascular dementia group(n=59)according to the presence or absence of the VD.The results showed that the serum levels of Lp-PLA2 and MMP-9 in vascular dementia group were significantly higher than those in non-vascular dementia group,and the levels of the two indicators were increased with the aggravation of the disease.The results indicated that there was a positive correlation between serum Lp-PLA2 and MMP-9 levels in the vascular dementia,which are expected to be used as predictors of AIS induced vascular dementia.

关 键 词：脂蛋白相关磷脂酶A2 基质金属蛋白酶-9 缺血性脑卒中 血管性痴呆 相关性 

分 类 号：R743[医药卫生—神经病学与精神病学]