miR-34a靶向调控SOX7表达抑制垂体腺瘤细胞增殖  

Inhibitory effect of miR-34a on the proliferation of pituitary adenoma cell by targeting SOX7

作　　者：张笑天 张莉莉 孙苏安[1] ZHANG Xiaotian;ZHANG Lili;SUN Su'an(Department of Pathology,Huaian First Hospital Affiliated to Nanjing Medical University,Huaian 223300,Jiangsu,China)

机构地区：[1]南京医科大学附属淮安第一医院病理科,江苏淮安223300

出　　处：《中南医学科学杂志》2020年第6期588-591,603,共5页Medical Science Journal of Central South China

摘　　要：探讨miR-34a通过靶向调控SOX7表达对垂体腺瘤细胞增殖的影响。结果显示,miR-34a mimics转染组和siRNA-SOX7组细胞活力、S期、G2期分别低于NC-miR-34a转染组和NC-SOX7转染组,细胞凋亡率和G1期分别高于NC-miR-34a转染组和NC-SOX7转染组。miR-34a mimics转染组SOX7 mRNA、SOX7蛋白的相对表达量低于NC-miR-34a转染组。结果表明,miR-34a可以通过靶向抑制SOX7表达抑制垂体腺瘤细胞增殖。To investigate the effects of miR-34a on the proliferation of pituitary adenoma cell through the targeted regulation of SOX7 expression.The results showed that the cell vitality,S and G2 phases of the miR-34a mimics transfection group and siRNA-SOX7 transfection group were lower than those of the NC-miR-34a transfection group and the NC-SOX7 transfection group,respectively,and the apoptosis rate and G1 phase were higher than those of the NC-miR-34a transfection group and the NC-SOX7 transfection group,respectively.The relative expression levels of SOX7 mRNA and SOX7 protein in miR-34a mimics transfection group were lower than those in NC-miR-34a transfection group.The results indicated that miR-34a can inhibit the proliferation of pituitary adenoma cell by inhibiting SOX7 expression.

关 键 词：MIR-34A SOX7 垂体腺瘤细胞 增殖 

分 类 号：R736.4[医药卫生—肿瘤]