肝动脉介入栓塞治疗肝癌合并门静脉瘤栓50例效果观察  

Effect of interventional embolization in the treatment of liver cancer with portal vein tumor thrombus

作　　者：吴建男 Wu Jiannan(Department of Gastroenterology,the People's Hospital of Putuo District of Zhoushan City,Zhoushan,Zhejiang 316100,China)

机构地区：[1]舟山市普陀区人民医院消化科,浙江省316100

出　　处：《中国基层医药》2020年第23期2830-2834,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省舟山市医药卫生科技计划项目(2015A22)。

摘　　要：目的:探讨放射介入栓塞治疗肝癌合并门静脉瘤栓的效果及其对患者生存质量的影响。方法:选取舟山市普陀区医院2017年7月至2019年7月就诊的肝癌合并门静脉瘤栓患者100例为研究对象,采用随机数字表法分为观察组和对照组各50例。对照组采用单纯肝动脉化疗药物灌注治疗,观察组采用放射介入肝动脉栓塞化疗。比较两组治疗效果、肝功能变化及生存质量评分。结果:观察组肝肿瘤缩小>50%25例(50%)、门静脉瘤栓消失10例(20%),对照组分别为16例(32%)、5例(10%),两组差异均有统计学意义(χ2=6.310、4.601,均P<0.05);治疗后,观察组血清白蛋白、丙氨酸氨基转移酶、白蛋白、血小板计数、白细胞计数分别为(23.80±10.60)μmol/L、(68.10±19.83)U/L、(338.60±50.16)g/L、(102.13±20.10)×109/L、(4.10±2.10)×109/L,对照组分别为(19.20±7.55)μmol/L、(64.10±11.25)U/L、(32.11±4.83)g/L、(110.45±28.64)×109/L、(4.83±2.83)×109/L,两组差异均有统计学意义(t=7.158、4.301、82.441、3.432、3.645,均P<0.05);观察组生存质量总健康评分为(69.20±3.94)分,高于对照组的(52.76±2.40)分(t=25.303,P<0.05)。结论:放射介入栓塞肝动脉治疗肝癌合并门静脉瘤栓能缩小肝癌或消除门静脉瘤栓,改善患者肝功能,提高患者生存质量,效果优于单纯肝动脉化疗药物灌注治疗。Objective To investigate the effect of radiological interventional embolization in the treatment of hepatocellular carcinoma with portal vein tumor thrombus,and its effect on the improvement of prognosis.Methods A total of 100 cases of liver cancer with portal vein tumor thrombus from July 2017 to July 2019 in the People's Hospital of Putuo District of Zhoushan City were selected in the study.The patients were divided into observation group and control group according to the random digital table method,with 50 cases in each group.The control group was treated by hepatic artery chemotherapy alone,and the observation group was treated by transcatheter arterial chemoembolization.The therapeutic effect,liver function changes and quality of life scores were compared between the two groups.Results In the observation group,25 cases(50%)with liver tumor shrinking more than 50%,10 cases(20%)with portal vein tumor thrombus disappearing,those were 16 cases(32%)and 5 cases(10%)in the control group,the differences were statistically significant between the groups(χ2=6.310,4.601,all P<0.05).After treatment,the serum albumin,alanine aminotransferase,albumin,platelet count and leukocyte count in the observation group were(23.80±10.60)μmol/L,(68.10±19.83)U/L,(338.60±50.16)g/L,(102.13±20.10)×109/L,(4.10±2.10)×109/L,respectively,which in the control group were(19.20±7.55)μmol/L,(64.10±11.25)U/L,(32.11±4.83)g/L,(110.45±28.64)×109/L,(4.83±2.83)×109/L,respectively,the differences between the two groups were statistically significant(t=7.158,4.301,82.441,3.432,3.645,all P<0.05).The total health score of quality of life in the observation group was(69.20±3.94)points,which was higher than that in the control group[(52.76±2.40)points](t=25.303,P<0.05).Conclusions Radiation interventional embolization for liver cancer with portal vein tumor thrombus can rapidly improve liver function and reduce liver cancer or portal vein tumor thrombus lesions.The effect is significant,which is of great significance for improving the qu

关 键 词：肝肿瘤 放射学 介入性 栓塞 治疗性 化学疗法 癌 局部灌注 生活质量 肝功能试验 疗效比较研究 

分 类 号：R735.7[医药卫生—肿瘤]