蜂胶中咖啡酸苯乙酯的合成及应用研究进展  

Research progress on synthesis and application of caffeic acid phenethyl ester in propolis

作　　者：张梅梅 谢英花[1] 刘朝霞 张冬梅 ZHANG Meimei;XIE Yinghua;LIU Zhaoxia;ZHANG Dongmei(School of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang,Hebei 050018,China)

机构地区：[1]河北科技大学化学与制药工程学院,河北石家庄050018

出　　处：《河北科技大学学报》2020年第6期528-536,共9页Journal of Hebei University of Science and Technology

基　　金：国家自然科学基金(81872770,51205204);河北省高等学校科学技术研究重点项目(ZD2017032);河北省大学生创新创业训练计划项目(201810082027)。

摘　　要：蜂胶具有丰富而突出的生物活性,目前多被应用于食品和保健品中预防疾病。咖啡酸苯乙酯是蜂胶中主要的有效成分,因其具有抗氧化、抗炎、抗肿瘤、抗菌、免疫调节等多种药理作用而备受关注。咖啡酸苯乙酯在自然界含量偏低,传统提取方法费时费力、成本高,高效、大量制备咖啡酸苯乙酯成为研究热点。超声提取技术可得到纯度较高的咖啡酸苯乙酯;Knoevenagel缩合法适用于其工业化生产,收率较高。通过对咖啡酸苯乙酯的提取分离、合成方法以及药理活性等方面的最新研究进展进行分析,综述了咖啡酸苯乙酯的研究现状,并对咖啡酸苯乙酯的技术发展前景和研究动向进行了展望,提出今后应寻求实用性和通用性高、操作相对简便的制备方法并对其作用机制进行更加深入细致的探究。Propolis has been widely used in foods and health care products to prevent diseases due to its various and prominent biological activities.Caffeic acid phenethyl ester(CAPE)is the main active component of propolis,which has been widely studied for its various pharmacological effects such as antioxidation,anti-inflammation,antitumor,antibacterial activities,immunovegularion,and so on.The content of CAPE is very low in nature,and the traditional extraction method of CAPE is time-consuming and costly,so efficient and mass preparation for CAPE has become a research hotspot.The CAPE with high purity can be obtained by ultrasonic extraction.Knoevenagel condensation reaction can be applied to its industrial production with high yield.Based on the analysis of the latest progress in extraction and separation,synthetic methods,pharmacological activity,and other aspects of CAPE,the research status of CAPE was reviewed,and the development prospect and the research trend of CAPE were provided,which are to explore the preparation method with high practicability and generality and relatively simple operation,and to conduct in-depth and detailed research on the mechanism of CAPE.

关 键 词：药物化学 蜂胶 咖啡酸苯乙酯 合成方法 药理活性 

分 类 号：R284.2[医药卫生—中药学] S896[医药卫生—中医学]