血常规和血生化指标在患强直性脊柱炎食蟹猴中的临床价值  

Clinical value of routine blood test and biochemical indexes in cynomolgus monkeys with ankylosing spondylitis

作　　者：李玉莹 麦冬梅 贾欢欢[2] 吴志恒 何刚华 唐爽捷 马承红 卢丽[1] LI Yuying;MAI Dongmei;JIA Huanhuan;WU Zhiheng;HE Ganghua;TANG Shuangjie;MA Chenghong;LU Li(Guangdong Pharmaceutical University,Guangzhou 511400,China;Guangdong Laboratory Animals Monitoring Institute(Guangdong Provincial Key Laboratory of Laboratory Animals),Guangzhou 510663;Guangzhou Blooming-Spring Biological Research Institute Co.,LTD,Guangzhou 510900;First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou 510000)

机构地区：[1]广东药科大学,广州511400 [2]广东省实验动物监测所(广东省实验动物重点实验室),广州510663 [3]广州春盛生物研究院有限公司,广州510900 [4]广东药科大学附属第一医院,广州510000

出　　处：《中国比较医学杂志》2020年第11期10-15,共6页Chinese Journal of Comparative Medicine

基　　金：广东省科技计划项目(2017A070701003);广东省科技计划项目(2019A030317009);国家自然科学基金项目(81941010)。

摘　　要：目的探讨部分血常规(WBC、PLT、MPV、NEUT、LYMPH、MONO、EO、BASO、NLR、MLR、ELR)和血生化指标(TP、ALB、A/G、GLOB、TG、CHO、HDL-C、LDL-C、ALP)对患有强直性脊柱炎的食蟹猴的临床价值。方法随机选取40只患强直性脊柱炎的食蟹猴和40只正常食蟹猴,检测两组食蟹猴中部分血常规与血生化指标。分别用秩和检验和独立样本t检验对比分析两组间是否存在差异,并利用受试者工作特征曲线(ROC)计算各指标的灵敏度、特异度和AUC值。结果在血常规指标中,除PLT外,强直性脊柱炎组中WBC、MPV、NEUT、LYMPH、MONO、EO、BASO、NLR、MLR、ELR均显著高于对照组,且各指标比值指标的AUC值均接近0.9;在血生化中,除TG无显著性差异外,强直性脊柱炎组中HDL-C、LDL-C、TP和ALB均显著低于对照组,GLOB、ALP和CHO显著高于对照组,ALP和GLOB的AUC值均大于0.9。结论本研究筛查的各种血常规和血生化指标可作为强直性脊柱炎食蟹猴筛查及药物评价的关键指标,并对强直性脊柱炎的后续研究提供重要参考。Objective To investigate the clinical value of routine blood test indexes(WBC,PLT,MPV,NEUT,LYMPH,MONO,EO,BASO,NLR,MLR,and ELR)and blood biochemical indexes(TP,ALB,A/G,GLOB,TG,CHO,HDL-C,LDL-C,and ALP)in cynomolgus monkeys with ankylosing spondylitis.Methods Forty cynomolgus monkeys with ankylosing spondylitis and 80 normal cynomolgus monkeys were selected and measured for routine blood test indicators and blood biochemical indicators.Comparisons between the two groups were performed using the rank sum test and t test method.In addition,the sensitivity,specificity,and area-und-the-curve(AUC)values of each index were calculated using receiver operator characteristic curve analysis.Results For routine blood indexes,with the exception of PLT,values of WBC,MPV,NEUT,LYMPH,MONO,EO,BASO,NLR,MLR,and ELR for the ankylosing spondylitis group were significantly higher than those of normal cynomolgus monkeys,and AUC values of the WBC ratio index were close to 0.9.Moreover,blood biochemistry indexes(with the exception of TG,HDL-C,LDL-C,TP,and ALB)in the ankylosing spondylitis group were significantly lower than those in control group.In addition,GLOB,CHO,and white ALP of the ankylosing spondylitis group were significantly higher compared with the control group.Conclusions Routine blood and blood biochemical indexes screened in this study can be used as screening and drug evaluation indexes of cynomolgus monkeys with ankylosing spondylitis,and provide important reference for clinical diagnosis of ankylosing spondylitis.

关 键 词：食蟹猴 强直性脊柱炎 血常规 血生化 

分 类 号：R-33[医药卫生]