常用哮喘动物模型的建立  

Establishment of common animal models of asthma

作　　者：李泳兴 钟鸣[1] 王勇[1] 马武华[1] LI Yongxing;ZHONG Ming;WANG Yong;MA Wuhua(Department of Anesthesiology,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一附属医院麻醉科,广州510405

出　　处：《中国比较医学杂志》2020年第11期97-101,共5页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(81704167,81673922,81503663)。

摘　　要：哮喘是一种常见的慢性呼吸系统炎症性疾病。与哮喘相关的病理生理学研究或者新药物试验需要建立相对应的哮喘动物模型。然而,到目前为止还没有一个理想的模型能够代表人类哮喘这种复杂疾病的所有特征。因此,本综述提供了目前用来制作哮喘模型的常用动物的特点、不同的造模方法和所选试剂以及造模所需的时间,有助于研究者根据研究设计选择合适的动物、方法和试剂。Asthma is a common chronic respiratory inflammatory disease.Additional asthma-related pathophysiology research and new drug trials are needed.This would be greatly expedited using corresponding animal asthma models.However,to date,there is no ideal model that can represent all the characteristics of the complex disease of human asthma.Therefore,this review provides the characteristics of commonly used animals currently used to make asthma models,different modeling method,different selected reagents,and the time required for modeling,which should help researchers in choosing appropriate animals,methods and allergens.

关 键 词：哮喘 动物模型 造模时间 

分 类 号：R-33[医药卫生]