阿莫西林分散片治疗上呼吸道感染药代动力学研究  

Pharmacokinetics of Amoxicillin Dispersible Tablets for Upper Respiratory Tract Infections

作　　者：刘恩峰[1] Liu Enfeng(Department of Pharmacy, Linyi Mental Health Center,Linyi,Shandong 276000)

机构地区：[1]山东省临沂市精神卫生中心药剂科,山东临沂276000

出　　处：《中外女性健康研究》2020年第22期4-5,共2页Women＇s Health Research

摘　　要：目的探究阿莫西林分散片治疗上呼吸道感染药代动力学。方法选取本院260例上呼吸道感染患者,随机分成观察组和对照组,对照组使用阿莫西林胶囊治疗,观察组则使用阿莫西林分散片治疗,两组药物用法和用量相同。治疗结束后,比较两组疗效及两组患者体内血液中药物浓度最大值、药物到达峰值时间、药物在体内分布半衰期的变化。结果干预后,观察组患者临床有效率以及体内血液中药物浓度最大值、药物到达峰值时间、药物在体内分布半衰期的变化均显著优于对照组,差异显著,P<0.05。结论把阿莫西林分散片应用到上呼吸道感染的治疗中,可以取得令人满意的临床效果。Objective:To investigate the pharmacokinetics of amoxicillin dispersible tablets for upper respiratory tract infections.Methods A total of 260 patients with respiratory infection in our hospital were selected.They were divided into observation group and control group.The control group was treated with amoxicillin capsules.The observation group was treated with amoxicillin dispersible tablets.The two groups had the same usage and dosage.After treatment,the effects of the two groups were compared,and the changes in the maximum drug concentration in blood,the time to peak drug value,and the half-life of drug distribution in the body were compared between the two groups.Results After the intervention,the clinical effectiveness of the observation group,the maximum concentration of drug in the blood,the time to reach the peak value of the drug,and the half-life distribution of the drug in the body were significantly better than those in the control group,with significant differences,P<0.05.Conclusion The application of amoxicillin dispersible tablets in the treatment of upper respiratory tract infections can achieve satisfactory clinical results.

关 键 词：阿莫西林分散片 上呼吸道感染 药代动力学 

分 类 号：R57[医药卫生—消化系统]