通天灸刺联合多巴丝肼片治疗帕金森病临床研究  

Clinical Effect on Tongtian Intradermal Injection Combined with Levodopa and Benserazide Tablets for Parkinson Disease

作　　者：陈有国 邱金珠 朱成秀 陈加孙 CHEN Youguo;QIU Jinzhu;ZHU Chengxiu;CHEN Jiasun

机构地区：[1]南方科技大学第二附属医院,广东深圳518112

出　　处：《新中医》2020年第21期91-95,共5页New Chinese Medicine

基　　金：深圳市地方级领军人才项目(20171205285D);深龙英才项目(2018010513B);深圳市实用型临床医学人才项目(SY2014013)。

摘　　要：目的:观察通天灸刺联合多巴丝肼片治疗帕金森病(PD)的临床疗效及对患者血瘀状态的影响。方法:将60例PD患者随机分为观察组和对照组,每组30例。对照组给予多巴丝肼片治疗,观察组在对照组基础上加用通天灸刺治疗,2组均治疗3个月。检测2组治疗前后血清脂质过氧化物(LPO)、超氧化物歧化酶(SOD)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、纤维蛋白原(FBG)、D-二聚体(D-D)、血小板计数(BPC)及脑内多巴胺(DA)、5-羟色胺(5-HT)水平,记录2组治疗前后血瘀证证候评分,比较2组治疗前后改良Webster症状量表评分及临床疗效。结果:治疗后,2组血清IL-1β、TNF-α、FBG、D-D、BPC水平及观察组LPO、SOD水平均较治疗前降低(P<0.05),观察组上述7项血清学指标均低于对照组(P<0.05)。治疗后,观察组脑内DA、5-HT水平均较治疗前升高,且均高于对照组,差异均有统计学意义(P<0.05)。对照组脑内DA、5-HT水平治疗前后比较,差异均无统计学意义(P>0.05)。治疗后,2组肢体颤抖、舌象、脉象、唇色、皮下瘀斑、肌肤甲错评分均较治疗前降低(P<0.05),观察组上述6项血瘀证证候评分均较对照组降低更明显(P<0.05)。治疗后,2组改良Webster症状量表评分均较治疗前降低(P<0.05),观察组改良Webster症状量表评分较对照组降低更明显(P<0.05)。治疗结束6个月后随访,观察组改良Webster症状量表评分低于对照组(P<0.05)。观察组总有效率为93.3%,高于对照组的76.7%(P<0.05)。结论:通天灸刺配合多巴丝肼片治疗PD,可以提高临床疗效,改善血瘀状态。Objective: To observe the clinical effect of tongtian intradermal injection combined with levodopa and benserazide tablets for Parkinson disease(PD) and its effect on blood stasis. Methods:A total of 60 cases of PD patients were randomly divided into the observation group and the control group,30 cases in each group. The control group was given levodopa and benserazide tablets,and the observation group was additionally treated with tongtian intradermal injection based on the treatment of the control group. Both groups were treated for three months. Before and after treatment,the levels of lipid peroxide(LPO),superoxide dismutase(SOD),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α), fibrinogen(FBG), D-dimer(D-D) and blood platelet count(BPC) in serum, as well as dopamine(DA) and5-hydroxytryptamine(5-HT) in the brain were detected in the two groups. The scores of blood stasis syndrome before and after treatment were recorded in the two groups. The scores of modified Webster Rating Scale before and after treatment,and the clinical effect after treatment were compared between the two groups. Results:After treatment,the levels of IL-1β,TNF-α,FBG,D-D and BPC in serum in the two groups,as well as the levels of LPO and SOD in the observation group were decreased when compared with those before treatment(P<0.05);the seven serum indexes above in the observation group were lower than those in the control group(P<0.05). After treatment,the levels of DA and 5-HT in the brain in the observation group were increased when compared with those before treatment,higher than those in the control group after treatment,differences being significant(P<0.05). In the control group,there was no significance being found in differences when compared the levels of DA and 5-HT in the brain with those before and after treatment(P>0.05). After treatment,the scores of limb shaking,tongue manifestation,pulse condition,lip color,subdermal ecchymosis,and scaly skin in the two groups were decreased when compared with those before treatment

关 键 词：帕金森病 通天灸刺 多巴丝肼片 血瘀 促炎因子 神经递质 脂质过氧化物 超氧化物歧化酶 

分 类 号：R742.5[医药卫生—神经病学与精神病学]