健康体检人群幽门螺杆菌感染程度与血清胃蛋白酶原、胃泌素17的相关性分析  

Correlation analysis of Helicobacter pylori infection with serum pepsinogen and gastrin-17 in physical examination population

作　　者：余结根[1] 李荣 刘少锋 唐梦莎[1] 徐朋辉[1] 姚应水 YU Jiegen;LI Rong;LIU Shaofeng;TANG Mengsha;XU Penghui;YAO Yingshui(Department of Management,Wannan Medical College,Wuhu 241002,China)

机构地区：[1]皖南医学院管理学教研室,安徽芜湖241002 [2]皖南医学院公共卫生学院慢性病防制研究所,安徽芜湖241002 [3]皖南医学院第一附属医院弋矶山医院健康管理中心,安徽芜湖241001 [4]皖南医学院第一附属医院弋矶山医院消化内科,安徽芜湖241001 [5]安徽中医药高等专科学校医疗系,安徽芜湖241003

出　　处：《皖南医学院学报》2020年第6期587-590,共4页Journal of Wannan Medical College

基　　金：安徽高校省级人文社会科学研究重点项目(SK2018A0190);安徽省哲学社会科学规划项目(AHSKY2018D55);安徽省第五批“特支计划”创新领军人才(T000516)。

摘　　要：目的:探讨幽门螺杆菌(HP)感染程度在健康体检人群中的分布情况及其与血清胃蛋白酶原(PG)、胃泌素17(G-17)水平的关系。方法:参与健康体检的5592人,采用14 C-尿素呼气试验检测受检者HP感染程度,酶联免疫法(ELISA)分别测定空腹G-17、PG水平,计算血清G-17、PG中位数水平及PGR(PGⅠ/PGⅡ)。结果:男性体检者HP阳性感染率(32.6%)低于女性体检者(36.4%),差异有统计学意义(P<0.05)。40~60岁年龄段受检者HP阳性率高于<40岁和>60岁年龄段受检者。HP阳性者PGⅠ、PGⅡ和G-17检测水平均高于HP阴性者(P<0.05),PGR检测水平低于HP阴性者(P<0.05);但HP不同感染程度体检者PGⅠ、PGR和G-17检测水平差异均无统计学意义(P>0.05)。HP感染程度为+++体检者PGⅡ检测水平高于HP+者(P<0.05);单HP感染程度为+和++体检者、++和+++体检者间PGⅡ检测水平差异均无统计学意义(P>0.05)。相关性分析显示体检人群HP感染程度与血清PGⅠ、PGⅡ和G-17水平呈正相关;与血清PGR水平呈负相关,差异均有统计学意义(P<0.05)。结论:健康体检人群中HP感染状态与年龄、性别有一定关联;PG、G-17水平与HP感染程度有一定相关性;解读PG、G-17需考虑HP的影响。Objective:To investigate the distribution of Helicobacter pylori(H.pylori)infection and its relationship with serum pepsinogen(PG)and gastrin-17(G-17)level in population undergoing physical examination.Methods:Totally,5592 participants undergoing physical examination were included,and subjected to 14 C-urea breath test to detect the degree of H.pylori infection.ELISA was performed to respectively measure the level of PG and G-17,and the median ratio of serum PG(PGR,PG I/PGII)was calculated.Results:The positive rate of H.pylori infection was lower in male participants(32.6%)than in females(36.4%),and higher in participants aged under 40 years or over 60 years than in those between 40 and 60 years old(both P<0.05).The measured level of PGⅠ,PGⅡand G-17 was higher in participants with positive H.pylori than in those with negative H.pylori(P<0.05),and PGRwas also lower than in participants with negative H.pylori(P<0.05).However,the difference was insignificant in levels of PGⅠ,PGRand G-17 among participants with different severity of H.pylori infection(P>0.05).PGⅡlevel was higher in participants with H.pylori+++than in those H.pylori+(P<0.05),yet remained no significant difference in between participants with H.pylori+and++,as well as those with++and+++(P>0.05).Correlation analysis showed that the H.pylori infection severity was positively related to PGⅠ,PGⅡand G-17 levels,yet negatively to serum PGRin the physical examination subjects(P<0.05).Conclusion:H.pylori infection is associated with the age and gender as well as PG and G-17 level in the physical examination population,which suggests that interpretation of serum PG and G-17 should take the influence of H.pylori infection into account.

关 键 词：幽门螺杆菌 胃蛋白酶原 胃泌素17 健康体检人群 

分 类 号：R573[医药卫生—消化系统] R194.3[医药卫生—内科学]