Copper-Catalyzed Carbocyclization of Silyl Enol Ether Tethered Ynamides for Efficient and Practical Synthesis of 2-Azabicyclo[3.2.o] Compounds  

作　　者：En-He Huang Zhi-Xin Zhang SiHan Ye Yang Bo Chen Wen-Feng Luo Peng Cheng Qian Long-Wu Ye 

机构地区：[1]State Key Llaboratory of Physical Chemisty of Solid Surfaces and Key Laboratory for Chemical Biology of Fujian Province,Cllege of Chemistry ano.Chemical Engineering,Xiamen University,Xiamen,Fujian 361005,China [2]Institute of New Materials&Industry Technology,College of Chemistry&Materials Engineering,Wenzhou University,Wenzhou,hejiang 325035,China [3]State Key Laboratory of Organometollic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2020年第10期1086-1090,共5页中国化学（英文版）

基　　金：We are grateful for financial support from the National Natural Science Foundation of China(Nos.21772161 and 21622204);the Natural Science Foundation of Fujian Province of China(No.2019J02001);the President Research Funds from Xiamen University(No.20720180036);NFFTBS(No.J1310024),PCSIRT,and Science&Technology Cooperation Program of Xiamen(No.3502Z20183015).

摘　　要：Summary of main observation and conclusion An efficient copper-catalyzed carbocyclization of silyl enol ether tethered ynamides has been developed,allowing rapid and practical construction of diverse 2-azabicyclo[3.2.0]compounds in generally good to excellent yields with broad substrate scope under mild reaction conditions.Importantly,this protocol not only constitutes a rare example of non-noble metal-catalyzed alkyne carbocyclization,but also represents a rare cyclization on the B-position ofπu-tethered ynamides.The possibility of asymmetric carbocyclization via kinetic resolution also emerges.

关 键 词：conditions. CYCLIZATION CATALYZED 

分 类 号：O64[理学—物理化学]