重庆地区女性门诊患者人乳头瘤病毒感染特征分析  

Analysis of characteristics of human papillomavirus infection in female outpatients in Chongqing

作　　者：李思阅 李秋红[1] 邹琴 刘孟涓 周兴燕 邹伟 李春莉[1] LI Siyue;LI Qiuhong;ZOU Qin;LIU Mengjuan;ZHOU Xingyan;ZOU Wei;LI Chunli(Department of Clinical Laboratory,Chongqing Health Center for Women and Children,Chongqing 401147,China)

机构地区：[1]重庆市妇幼保健院检验科,重庆401147

出　　处：《国际检验医学杂志》2020年第23期2882-2887,2892,共7页International Journal of Laboratory Medicine

摘　　要：目的分析并探讨人乳头瘤病毒(HPV)在重庆地区女性门诊患者中的感染分布情况及流行病学特征。方法对17375例女性门诊患者宫颈脱落细胞标本进行HPV基因分型,分析HPV亚型在不同年龄层人群中的分布特征。结果17375例女性门诊患者中,HPV感染者共5144例(29.61%)。5144例感染者中单一感染3742例(72.74%),多重感染1402例(27.26%)。单一感染者中,高危、疑似高危、低危亚型患者占比分别为79.16%、11.65%、9.19%。多重感染中,以双重感染为主,占72.04%,最多出现九重感染。最常见的4种亚型依次为HPV52、HPV16、HPV58及HPV53。不同年龄层患者中,HPV感染率呈现“U”型分布特征,<20岁及≥70岁群体为感染的2个高峰,感染率分别为48.57%和62.96%。各年龄层均以单一高危型感染为主,其中60~<70岁、≥70岁、<20岁为高危型易感前3位群体。结论重庆地区女性门诊患者HPV感染流行与亚型分布具有较强的地域和年龄特性,进行地域针对性的疫苗研发可为本地区宫颈癌的预防控制提供更有效的途径。Objective To analyze and explore the distribution and epidemiological characteristics of human papillomavirus(HPV)infection in female outpatients in Chongqing.Methods HPV genotyping was performed on the cervical exfoliated cell samples of 17375 female outpatients,and the distribution characteristic of HPV subtypes in different age groups was analyzed.Results Among the 17375 female outpatients,5144 cases(29.61%)were infected with HPV.Among the 5144 infected patients,3742 cases(72.74%)were single infection and 1402 cases(27.26%)were multiple infection.In the single infection group,the proportions of high-risk,suspected high-risk and low-risk patients were 79.16%,11.65%,and 9.19%respectively.In the multiple infection group,double infection was the main one,accounting for 72.04%,and nine multiple infections occurred at most.The four most common subtypes were HPV52,HPV16,HPV58 and HPV53.In patients of different age groups,HPV infection rate showed a"U"-shaped distribution characteristics.The two peaks of HPV infection were<20 years old and≥70 years old group,the infection rates were 48.57%and 62.96%respectively.Single high-risk subtype infection was predominant in all age groups,and the top three susceptible groups were 60-70 years old,≥70 years old and<20 years old.Conclusion The prevalence and subtype distribution of HPV infection in female outpatients in Chongqing have distinctive regional and age characteristics,regionally specific vaccine research is an effective way to prevent and control cervical cancer in the region.

关 键 词：人乳头瘤病毒 宫颈癌 疫苗 

分 类 号：R737.33[医药卫生—肿瘤]