美罗培南与利奈唑胺对脑脓肿磁共振导航穿刺术后感染患者神经功能的影响对比  

Comparison of the Influence of Meropenem and Linezolid on the Neurological Function of Infected Patients after Magnetic Resonance Navigation Puncture of Brain Abscess

作　　者：刘建新 LIU Jianxin(Department of Neurosurgery,the First Affiliated Hospital of Zhengzhou University/the People's Hospital of Fengqiu County,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院/封丘县人民医院神经外科,河南郑州450000

出　　处：《临床医学工程》2020年第11期1509-1510,共2页Clinical Medicine & Engineering

摘　　要：目的探讨美罗培南与利奈唑胺对脑脓肿磁共振导航穿刺术后感染患者神经功能的影响。方法选取2017年9月至2019年8月我院收治的脑脓肿磁共振导航穿刺术后感染患者120例,随机分为美罗培南组(接受美罗培南治疗)与利奈唑胺组(接受利奈唑胺治疗)各60例。比较两组患者治疗前后的炎性因子(IL-8、 hs-CRP)水平及NIHSS评分。结果治疗前,两组的IL-8、 hs-CRP水平比较差异无统计学意义(P>0.05);治疗后,美罗培南组的IL-8、 hs-CRP水平均明显低于利奈唑胺组(P <0.05)。治疗前,两组患者的NIHSS评分比较差异无统计学意义(P>0.05);治疗后,美罗培南组的NIHSS评分明显低于利奈唑胺组(P <0.05)。结论与利奈唑胺相比,美罗培南在改善脑脓肿磁共振导航穿刺术后感染患者神经功能、降低其炎性反应方面效果更佳,值得临床推广。Objective To explore the influence of meropenem and linezolid on the neurological function of infected patients after magnetic resonance navigation puncture of brain abscess.Methods 120 infected patients after magnetic resonance navigation puncture of brain abscess admitted to our hospital from September 2017 to August 2019 were selected and randomly divided into meropenem group(treated with meropenem)and linezolid group(treated with linezolid),with 60 cases in each group.The levels of inflammatory factors(IL-8,hs-CRP)and the NIHSS scores before and after treatment were compared between the two groups.Results Before treatment,no statistical difference was found in the IL-8 and hs-CRP levels between the two groups(P>0.05).After treatment,the IL-8 and hs-CRP levels of the meropenem group were significantly lower than those of the linezolid group(P<0.05).Before treatment,no statistical difference was found in the NIHSS score between the two groups(P>0.05).After treatment,the NIHSS score of the meropenem group was significantly lower than that of the linezolid group(P<0.05).Conclusions Compared with linezolid,meropenem has better effect in improving the neurological function and reducing the inflammatory response of infected patients after magnetic resonance navigation puncture of brain abscess,which is worthy of clinical promotion.

关 键 词：美罗培南 利奈唑胺 脑脓肿 磁共振导航穿刺术 神经功能 

分 类 号：R742.7[医药卫生—神经病学与精神病学]