匹维溴铵联合丁溴东莨菪碱在内镜下逆行胰胆管造影术中的应用  

Application of Pinaverium Bromide combined with Scopolamine Butylbromide in endoscopic retrograde cholangiopancreatography

作　　者：王剑 陈维峰 刘元东 WANG-Jian;CHEN Wei-feng;LIU Yuan-dong(Department of Gastroenterology,Guangxin District People′s Hospital of Shangrao City,Jiangxi Province,Shangrao334100,China;Department of Gastroenterology,Yushan County Hospital of Traditional Chinese Medicine,Jiangxi Province,Yushan334700,China)

机构地区：[1]江西省上饶市广信区人民医院消化内科,江西上饶334100 [2]江西省玉山县中医院消化内科,江西玉山334700

出　　处：《中国当代医药》2020年第33期40-42,46,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(20204825)。

摘　　要：目的分析匹维溴铵联合丁溴东莨菪碱在内镜下逆行胰胆管造影术(ERCP)应用效果。方法选取江西省上饶市广信区人民医院消化内科在2018年1月~2020年2月收治的75例行内镜下逆行胰胆管造影术患者作为研究对象。按奇偶数分组法分为对照组(n=37)与观察组(n=38),对照组于术前30 min常规用药哌替啶、地西泮;观察组在常规使用哌替啶、地西泮用药基础上采用匹维溴铵联合丁溴东莨菪碱。比较两组患者成功插管时间,监测及比较患者术后3、24h时的血清淀粉酶含量;比较患者并发症发生情况及腹痛程度。结果观察组成功插管时间为(3.71±0.63)min,短于对照组的(5.48±0.72)min,术后3、24 h血清淀粉酶水平均低于对照组,腹痛程度低于对照组,差异有统计学意义(P<0.05);观察组术后并发症总发生率为2.63%,对照组术后并发症总发生率为16.22%,差异有统计学意义(P<0.05)。结论匹维溴铵联合丁溴东莨菪碱能够缩短内镜下逆行胰胆管造影术患者的插管时间,降低并发症发生率,腹痛感减轻明显,值得推广应用。Objective To analyze the application effect of Pinaveonium Bromide combined with Scopolamine butylbromide in endoscopic retrograde cholangiopancreatography(ERCP).Methods Seventy-five patients who underwent endoscopic retrograde cholangiopancreatography in the Department of Gastroenterology,Guangxin District People′s Hospital,Shangrao City,Jiangxi Province from January 2018 to February 2020 were selected.According to odd and even grouping method,they were divided into control group(n=37)and observation group(n=38).The control group used 30 minutes before surgery:Pethidine and Diazepam;the observation group used Pethidine and Diazepam routinely on the basis of pan medication,Pinaverium Bromide combined with Scopolamine Butylbromide to compare the successful intubation time of patients of the two groups,monitor and compare the serum amylase content at 3h and 24h after operation;compare the incidence of complications and abdominal pain in patients.Results The time of successful intubation in the observation group was(3.71±0.63)min,shorter than that in the control group of(5.48±0.72)min.The serum amylase level was lower than that in the control group at 3h and 24h after surgery,and the degree of abdominal pain was lower than that in the control group,with statistically significant differences(P<0.05).The total incidence of postoperative complications was 2.63%in the observation group and 16.22%in the control group,with statistically significant difference(P<0.05).Conclusion Pinaverium Bromide combined with Scopolamine Butylbromide can shorten the intubation time of patients with endoscopic retrograde cholangiopancreatography,reduce the incidence of complications,and reduce abdominal pain significantly,which is worth popularizing.

关 键 词：内镜下逆行胰胆管造影术 匹维溴铵 丁溴东莨菪碱 腹痛 

分 类 号：R576[医药卫生—消化系统]