TGF-β信号通路在纤维化疾病中的作用研究进展  

Research progress on the role of TGF-βsignaling pathway in fibrotic diseases

作　　者：范美玲 应苗法[1] 赵蕊[1] 金烨成 李明星 Fan Mei-Ling;Ying Miao-Fa;Zhao Rui;Jin Ye-Cheng;Li Ming-Xing(Department of Pharmacy,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院药剂科,杭州310016

出　　处：《解放军医学杂志》2020年第11期1171-1177,共7页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(8170140653);浙江省自然科学基金(LYY19H310010,LYY20H310002)。

摘　　要：纤维化疾病是由于机体受到多种刺激因子的作用,肌成纤维细胞活化或发生表型转化,使胶原蛋白表达增加及细胞外基质过度沉积,最终导致器官结构和功能受损的一类疾病。转化生长因子-β(TGF-β)是目前公认的参与纤维化疾病发生过程的调控因子,在调控肺、肝、心肌、肾及胰腺等纤维化疾病的发生、发展过程中具有重要作用。近年来,许多研究探讨了TGF-β信号通路在纤维化疾病发生中的作用,而抑制TGF-β信号通路活化即可起到抗纤维化的作用,但其机制尚未完全明确。该文就TGF-β信号通路在肺、肝、心肌、肾及胰腺等纤维化疾病中的作用进行综述,以期为纤维化疾病治疗靶点的选择提供新策略。Fibrotic disease is a type of disease in which the body is affected by various stimulating factors,which causes the activation or phenotypic transformation of myofibroblasts,increases the expression of collagen and excessive deposition of extracellular matrix,resulting in damage to the structure and function of organs.Transforming growth factor-β(TGF-β)is currently recognized as a signal transduction pathway involved in the occurrence of fibrotic diseases,and plays an important role in regulating the occurrence and development of fibrotic diseases such as lung,liver,myocardium,kidney and pancreas.In recent years,many studies have explored the role of TGF-βsignaling pathway in the occurrence and development of fibrotic diseases,while to inhibit the activation of TGF-βsignaling pathway might have anti-fibrosis effects,but the mechanism has not been fully understood.Therefore,the research progress of the role of TGF-βsignaling pathway in such fibrotic diseases as lung,liver,myocardium,kidney and pancreas,and so on,has mainly been reviewed in present paper,so as to provide new strategies for the selection of therapeutic targets for fibrotic diseases.

关 键 词：纤维化疾病 转化生长因子-Β 信号通路 作用机制 研究进展 

分 类 号：R363.2[医药卫生—病理学]