母体免疫系统及血液系统基因多态性与复发性自发流产相关性的研究进展  

Research progress on the relationship of the genetic polymorphism of maternal immune system and blood system to the recurrent spontaneous abortion

作　　者：张万生[1,2] 谢华[3] 薛智欣[3] 王雪楠[4] 吴迪 孙艳美[1] 潘晓燕[1] Zhang Wan-Sheng;Xie Hua;Xue Zhi-Xin;Wang Xue-Nan;Wu-Di;Sun Yan-Mei;Pan Xiao-Yan(Center for Reproductive Medicine,Jilin Medical College,Jilin City,Jilin Province 132013,China;Department of Urology Surgery,465 Hospital Affiliated to Jilin Medical College,Jilin City,Jilin Province 132013,China;Department of Gynecology,Jilin Central General Hospital,Jilin City,Jilin Province 132602,China;Department of Reproductive Medicine,Affiliated Hospital of Jining Medical College,Jining,Shandong 272029,China)

机构地区：[1]吉林医药学院生殖医学研究中心,吉林省吉林市132013 [2]吉林医药学院附属465医院泌尿外科,吉林省吉林市132013 [3]吉林市中心医院妇科,吉林省吉林市132602 [4]济宁医学院附属医院生殖科,山东济宁272029

出　　处：《解放军医学杂志》2020年第11期1190-1195,共6页Medical Journal of Chinese People's Liberation Army

基　　金：吉林省科技发展计划项目(20190304071YY,20200201132JC);吉林省卫生与健康青年科技骨干培养计划(2018Q047);吉林市科技创新发展计划项目(201831721,20190403224);吉林省教育厅“十三五”科学技术研究项目(JJKH20191065KJ,JJKH20200454KJ);吉林省大学生创新创业训练计划项目(201913706031,202013706019)。

摘　　要：复发性自发流产(RSA)是影响女性生殖健康的重要疾病,其发生率约为1%。RSA的病因复杂,其中遗传因素是常见的原因之一。近年大量研究表明RSA与相关基因的多态性密切相关。正常的胎儿发育需要胚胎的成功植入及妊娠的维持,母体的免疫系统及血液系统在其中起重要的调控作用。该文综述了母体免疫系统及血液系统相关基因多态性与RSA的相关性,旨在从基因水平阐述RSA的发病机制,为临床预防及治疗RSA提供准确可行的指导。Recurrent spontaneous abortion(RSA)is an important disease affecting female reproductive health,with an incidence of 1%-5%.The causes of RSA are complex,among which genetic factor is one of the common causes.A large number of studies in recent years have shown that RSA is closely related to the polymorphism of related genes.Normal fetal development requires the successful implantation of embryos and the maintenance of pregnancy,in which the maternal immune system and blood system play an important regulatory role.Therefore,the present paper summarized the relationship of the genetic polymorphism of maternal immune system and blood system to RSA,aiming to elucidate the pathogenesis of RSA at the gene level and provide accurate and feasible guidance for clinical prevention and treatment of RSA.

关 键 词：复发性自发流产 基因多态性 免疫系统 血液系统 

分 类 号：R394.1[医药卫生—医学遗传学]