补肾益肝方联合多巴丝肼片治疗肝肾不足型帕金森病临床观察  

Clinical Research on Tonifying Kidney and Benefiting Liver Prescription Combined with Levodopa and Benserazide Hydrocbloride Tablets in the Treatment of Parkinson’s Disease with Liver and Kidney Deficiency

作　　者：宋海燕[1] SONG Haiyan(Encephalopathy Department,Taian Hospital of Traditional Chinese Medicine,Shandong Province,Taian 271000,China)

机构地区：[1]泰安市中医医院脑病科,山东泰安271000

出　　处：《光明中医》2020年第22期3634-3637,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

摘　　要：目的观察补肾益肝方联合多巴丝肼片治疗肝肾不足型帕金森病的临床疗效。方法选取2015年6月—2018年3月就诊的肝肾不足型帕金森病患者80例,按照随机数字表法分为2组各40例,其中对照组脱落3例,有效病例37例;治疗组脱落5例,有效病例35例。对照组采用多巴丝肼片治疗,治疗组在对照组的基础上采用补肾益肝方治疗。2组均治疗3个月。结果治疗组总有效率为91. 43%,高于对照组的72. 97%(P <0. 05)。2组治疗后中医证候评分、焦虑评分、抑郁评分均低于治疗前(P <0. 05),且治疗组中医证候评分低于对照组(P <0. 05),但治疗组焦虑评分、抑郁评分与对照组比较,差异无统计学意义(P> 0. 05)。2组治疗后帕金森病睡眠量表(PDSS)评分均高于治疗前(P <0. 05),且治疗组高于对照组(P <0. 05)。治疗组治疗后注意与集中、执行功能、记忆、计算评分均高于治疗前(P <0. 05),对照组治疗后计算、定向力评分均高于治疗前(P <0. 05),且治疗组注意与集中、执行功能、记忆、计算评分高于对照组(P <0. 05)。2组不良反应发生率比较,差异无统计学意义(P> 0. 05)。结论补肾益肝方联合多巴丝肼片治疗肝肾不足型帕金森病,能够改善临床症状,提高认知功能、睡眠质量及临床疗效。Objective To observe the clinical efficacy of tonifying kidney and benefiting liver prescription combined with levodopa and benserazide hydrocbloride tablets in the treatment of Parkinson’s disease with liver and kidney deficiency. Methods A total of 80 patients with Parkinson’s disease with liver and kidney deficiency who were treated in our hospital from June 2015 to March 2018 were selected and divided into two groups according to the random number table method,with 40 cases in each group. Among them,there were 3 cases of abscission in the control group and 37 effective cases. In the treatment group,there were 5 cases of abscission and 35 effective cases. The control group was treated with levodopa and benserazide hydrocbloride tablets,and the treatment group was treated with tonifying kidney and benefiting liver prescription on the basis of the control group. Both groups were treated for 3 months. Results The total effective rate in the treatment group was 91. 43%,which was higher than that in the control group( 72. 97%)( P < 0. 05). After treatment,the TCM syndrome score,anxiety score,and depression score of the two groups were lower than before treatment( P < 0. 05),and the TCM syndrome score of the treatment group was lower than the control group( P < 0. 05),but the anxiety score and depression score of the treatment group compared with the control group,and the difference was not statistically significant( P > 0. 05). The PDSS score of both groups after treatment was higher than before treatment( P < 0. 05),and the treatment group was higher than the control group( P < 0. 05). The attention and concentration,executive function,memory,and calculated scores of the treatment group after treatment were higher than before treatment( P < 0. 05),the calculation and orientation score of the control group after treatment were higher than before treatment( P < 0. 05). After treatment,the attention and concentration,executive function,memory,and calculated score of the treatment group were higher than those of t

关 键 词：老年颤证 补肾益肝方 多巴丝肼片 肝肾不足证 帕金森病 中西医结合疗法 

分 类 号：R742.5[医药卫生—神经病学与精神病学]