抗血管内皮生长因子综合疗法在新生血管性青光眼患者中的应用  

Application of comprehensive therapy of anti-vascular endothelial growth factor in neovascular glaucoma

作　　者：钟珊[1] 曾思明[1] ZHONG Shan;ZENG Siming(Department of Ophthalmology,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,Guangxi,China)

机构地区：[1]广西壮族自治区人民医院眼科,广西南宁市530021

出　　处：《微创医学》2020年第5期598-601,共4页Journal of Minimally Invasive Medicine

基　　金：广西医疗卫生适宜技术开发与推广应用项目(编号:S201640)。

摘　　要：目的探讨抗血管内皮生长因子(VEGF)综合治疗新生血管性青光眼的疗效和安全性。方法回顾性分析60例(60眼)新生血管性青光眼患者的临床资料,其中接受玻璃体腔内注射康柏西普注射液联合复合式小梁切除术及全视网膜光凝术的30例患者为观察组,接受复合式小梁切除术联合全视网膜光凝术,未行玻璃体注药的30例患者为对照组。比较两组患者手术前后的眼压、视力改变情况、治疗成功率及并发症发生情况。结果术后3 d、7 d、1个月、3个月,两组患者眼压水平较术前均有显著降低;且观察组患者眼压水平低于对照组(均P<0.05)。两组患者术后视力改善程度比较,差异无统计学意义(P>0.05)。观察组患者治疗成功率显著高于对照组,总并发症发生率低于对照组(均P<0.05)。结论康柏西普玻璃体腔内注射联合复合式小梁切除术及视网膜光凝术治疗新生血管性青光眼能够有效降低眼压,保护残存视力,疗效安全可靠。Objective To investigate the efficacy and safety of anti-vascular endothelial growth factor(VEGF)in comprehensively treating neovascular glaucoma.Methods The clinical data of 60 patients(60 eyes)with neovascular glaucoma were retrospectively analyzed,of them,30 patients received intravitreal injection with conbercept combined with compound trabeculectomy and panretinal photocoagulation were selected as the observation group,while the other 30 patients received compound trabeculectomy combined with panretinal photocoagulation,but without intravitreal injection with conbercept were included in the control group.The pre-and post-operative intraocular pressure,visual acuity changes,treatment success rate and complications were compared between the two groups.Results At 3 days,7 days,1 month,3 months after the operation,the intraocular pressure levels of the two groups were significantly lower than those before operation,and the observation group had a lower level as compared with the control group(all P<0.05).There was no statistically significant difference in postoperative visual acuity improvement between the two groups(P>0.05).The observation group yielded a higher treatment success rate,whereas a lower incidence of total complications as compared to the control group(all P<0.05).Conclusion Conbercept intravitreal injection combined with compound trabeculectomy and panretinal photocoagulation in the treatment of neovascular glaucoma can effectively decrease intraocular pressure and protect residual visual acuity,and thus the efficacy is safe and reliable.

关 键 词：新生血管性青光眼 抗VEGF治疗 复合式小梁切除术 全视网膜光凝术 

分 类 号：R775[医药卫生—眼科]