Recent Developments in the Treatment of Wet Age-related Macular Degeneration  

作　　者：Zois Papadopoulos 

机构地区：[1]Department of Ophthalmology,Massachusetts Eye and Ear Infirmary,Harvard Medical School,Boston,Massachusetts,USA

出　　处：《Current Medical Science》2020年第5期851-857,共7页当代医学科学（英文）

摘　　要：Age-related macular degeneration(AMD)is the most common cause of irreversible blindness and visual impairment in individuals over the age of 50 years in western societies.More than 25 million people currently suffer from this illness in the world,with an additional 500000 every year,approximately.It is a multifactorial ocular disease that affects the maculae due to a late-onset progressive neurodegeneration and dysfunction of photoreceptors and retinal pigment epithelium(RPE).There are many subtypes of AMD but basically two broad forms:the nonneovascular(dry,nonexudative)and neovascular(wet,exudative).Exudative AMD is the less common form(about 15%)but tends to progress more rapidly.At the moment,wet AMD is treated primarily on the basis of anti-vascular endothelial growth factor(VEGF)agents,which have led to massive improvement in the prognosis of the disease since they were first introduced.This article focuses on the latest treatment approaches to neovascular AMD.An extensive literature review was performed in order to illustrate the effectiveness of current and future anti-VEGF agents as well as the landmark clinical studies that have been carried out to establish these drugs as a gold standard in the therapy of wet AMD.

关 键 词：neovascular age-related macular degeneration exudative AMD medical retina retinal diseases NEOVASCULARIZATION ANGIOGENESIS vascular endothelial growth factor 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]