瘤床同步加量调强放疗与序贯瘤床加量调强放疗治疗乳腺癌的临床效果观察  

Clinical efficacy of simultaneous integrated boost intensity-modulated radiotherapy and sequential boost intensity-modulated radiotherapy in breast cancer

作　　者：李恩萍[1] 史天云[1] 王博[1] 张欣萍[1] LI Enping;SHI Tianyun;WANG Bo;ZHANG Xinping(Department of Gynecology,Nanyang First People’s Hospital,Nanyang 473010,He’nan,China)

机构地区：[1]南阳市第一人民医院妇科,河南南阳4730100

出　　处：《癌症进展》2020年第21期2209-2212,共4页Oncology Progress

摘　　要：目的探讨瘤床同步加量调强放疗与序贯瘤床加量调强放疗治疗乳腺癌的临床效果。方法按照术后放疗方式的不同将84例行保乳手术的乳腺癌患者分为同步治疗组(n=43,行瘤床同步加量调强放疗)和序贯治疗组(n=41,行序贯瘤床加量调强放疗)。比较两组患者的放疗时间、乳房美容效果、放疗相关不良反应发生情况、术后5年总生存率、术后5年无进展生存率。结果同步治疗组患者的放疗时间短于序贯治疗组患者(P﹤0.05)。放疗后,两组患者的乳房美容优良率比较,差异无统计学意义(P﹥0.05)。两组患者均发生了白细胞减少、血小板减少、贫血、胃肠道反应、肝功能不全、肾功能不全、心功能损害、皮肤反应,但两组患者的各不良反应发生情况比较,差异均无统计学意义(P﹥0.05)。两组患者的5年无进展生存率和5年总生存率比较,差异均无统计学意义(P﹥0.05)。结论瘤床同步加量调强放疗可以明显缩短乳腺癌患者的放疗总时间,在保证乳房美容效果和远期生存情况的同时,未增加放疗相关不良反应。Objective To investigate the clinical efficacy of simultaneous integrated boost intensity-modulated radiotherapy and sequential boost intensity-modulated radiotherapy in breast cancer.Method 84 breast cancer patients undergoing breast-conserving surgery were divided into the simultaneous treatment group(n=43,treated with simultaneous integrated boost intensity-modulated radiotherapy)and the sequential treatment group(n=41,treated with sequential boost intensity-modulated radiotherapy)according to different postoperative radiotherapy.The radiotherapy time,cosmetic effect of breast,incidence of adverse reactions associated with radiotherapy,5-year overall survival rate and 5-year progression-free survival rate were compared between the two groups.Result The radiotherapy time of patients in simultaneous treatment group was shorter than that in sequential treatment group(P<0.05).There was no significant difference in the excellent rate of breast cosmetic effect between two groups after radiotherapy(P>0.05).Leukopenia,thrombocytopenia,anemia,gastrointestinal reaction,liver dysfunction,renal insufficiency,heart function damage and skin reaction occurred in both groups,but without significant differences(P>0.05).There were no significant differences for the 5-year overall survival rate and 5-year progression-free survival rate between the two groups(P>0.05).Conclusion Simultaneous integrated boost intensity-modulated radiotherapy can significantly shorten the total radiotherapy time without increase of adverse reactions in ensuring cosmetic effect of breast and long term survival.

关 键 词：乳腺癌 瘤床同步加量调强放疗 序贯瘤床加量调强放疗 不良反应 临床疗效 

分 类 号：R737.9[医药卫生—肿瘤]