κ-阿片受体在应激反应中的研究进展  

Research progress of kappa opioid receptor in stress response

作　　者：陈大艳 陈炳利 吴碧华[2] Chen Dayan;Chen Bingli;Wu Bihua(Neurology Department,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Geriatric Department,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院神经内科,南充637000 [2]川北医学院附属医院老年科,南充637000

出　　处：《神经疾病与精神卫生》2020年第8期600-604,共5页Journal of Neuroscience and Mental Health

摘　　要：应激是机体对挑战的反应,可对机体产生重大影响,但抗焦虑抑郁和稳定心境类药物选择面窄且存在不良反应多、起效慢等诸多问题;阿片受体对于情绪的调节作用成为近年的研究热点,既往国内外的研究均主要集中于δ-阿片受体,而近年来κ-阿片受体的情绪调节作用得到重视;现对κ阿片受体与应激相关的分子途径及其相互作用进行综述,以期为下一步的研究提供支持。Stress is the body's response to challenges and has a significant impact on the body.However the choice of anti-anxiety,depression and mood stabilizers is narrow,and there are many problems such as side effects and slow onset.The emotional regulation of opioid receptors has become a hot topic in recent years.Previous studies at home and abroad mainly focus onδ-opioid receptors,whileκ-opioid receptors'emotional regulation has been paid more attention in recent years.In this paper,the molecular pathways of stress related toκ-opioid receptors and the interactions between different brain regions are reviewed in order to provide support for further research.

关 键 词：Κ-阿片受体 情绪障碍 应激反应 综述 

分 类 号：R749[医药卫生—神经病学与精神病学]