抑郁症神经炎症机制的研究进展  

Reseach progress in neuroinflammation mechanism in depression

作　　者：欧雯雯 张燕[1] 刘帮杉 郑琪 陈文涛 柳进 廖梅[1] OUWenwen;ZHANG Yan;LIU Bangshan;ZHENG Qi;CHENWentao;LIU Jin;LIAO Mei(Institute of Mental Health,Central South University,National Clinical Research Center for Mental Disorders,National Technology Institute on Mental Disorders,Hunan Key Laboratory of Psychiatry and Mental Health,Changsha 410011;Xiamen Xianyue Hospital,Xiamen Mental Health Center,Xiamen Fujian 361012,China)

机构地区：[1]中南大学精神卫生研究所,国家精神心理疾病临床医学研究中心,精神疾病诊治技术国家地方联合工程实验室,精神病与精神卫生学湖南省重点实验室,长沙410011 [2]厦门市仙岳医院,厦门市精神卫生中心,福建厦门361012

出　　处：《中南大学学报（医学版）》2020年第11期1372-1377,共6页Journal of Central South University ：Medical Science

摘　　要：神经炎症是中枢神经系统的先天免疫反应,以小胶质细胞激活为特征性表现,可伴有星形胶质细胞激活、炎症因子及趋化因子水平增高。研究发现抑郁症患者存在神经炎症的特征性改变,主要表现为相关脑区中小胶质细胞激活。目前临床上利用正电子发射体层摄影技术发现抑郁症患者脑内神经炎症影像学标志物的表达上调。Neuroinflammation is the innate immune response of the central nervous system,characterized by microglia activation,which can be accompanied with activation of astrocytes and increased levels of inflammatory factors and chemokines.Recent studies indicate that depressive patients have characteristic changes in neuroinflammation,mainly characterized by activation of microglia in the relevant brain regions.At present,the clinical results of positron emission tomography have found that the expression of neuroinflammatory imaging markers in the brain of patients with depression is increased.

关 键 词：抑郁症 神经炎症 小胶质细胞 转位蛋白 

分 类 号：R749.4[医药卫生—神经病学与精神病学]