温胆益脑汤对老年帕金森病患者认知功能与血清因子水平的影响  

Effect of Wendan Yinao Decoction on Cognitive Function and Serum Factor Level in Elderly Patients with Parkinson’s Diseas

作　　者：刘欣[1] LIU Xin(Department of Neurology,the Fourth Affiliated Hospital of China Medical University,Liaoning Province,Shenyang 110034,China)

机构地区：[1]中国医科大学附属第四医院神经内科,辽宁沈阳110034

出　　处：《中国中医药现代远程教育》2020年第22期67-69,共3页Chinese Medicine Modern Distance Education of China

摘　　要：目的对老年帕金森病患者应用温胆益脑汤治疗,分析该治疗方案对患者血清因子水平的影响。方法按照随机数字表法将2017年2月—2019年1月收治的104例老年帕金森病患者分为对照组和观察组,各52例。对照组应用常规西药治疗,观察组在对照组基础上应用温胆益脑汤治疗,观察并分析2组患者临床疗效及血清因子水平。结果观察组患者治疗总有效率(92.31%)较对照组总有效率(69.23%)高,差异有统计学意义(P<0.05);2组患者治疗后血清YKL-40、IL-1β、BDNF水平均较治疗前有明显改善,且观察组YKL-40、IL-1β水平低于对照组,BDNF水平高于对照组,差异有统计学意义(P<0.05)。结论针对老年PD患者应用温胆益脑汤可有效改善其神经功能,促进认知功能恢复,进而提高整体的治疗效果。Objective To analyze the effect of Wendan Yinao decoction on serum factor level in elderly patients with Parkinson’s disease(PD).Methods 104 elderly patients with Parkinson’s disease treated in our hospital from February 2017 to January 2019 were divided into control group(n=52)and observation group(n=52).The control group was treated with conventional western medicine,and the observation group was treated with Wendan Yinao decoction on the basis of the control group.The clinical efficacy and serum factor level of the two groups were observed and analyzed.Results the total effective rate of the patients in the observation group(92.31%)was higher than that in the control group(6923%).The levels of serum YKL-40,IL-1βand BDNF in the two groups were significantly improved after treatment,and the levels of YKL-40,IL-1βin the observation group were lower than those in the control group,and the level of BDNF in the observation group was significantly higher than that in the control group(P<0.05).Conclusion The application of Wendan Yinao decoction in elderly patients with PD can effectively improve its neurological function,promote the recovery of cognitive function,and then improve the overall therapeutic effect.

关 键 词：老年病 帕金森病 温胆益脑汤 血清因子 认知功能 癫证 

分 类 号：R742.5[医药卫生—神经病学与精神病学]