TNF-α及CCR5Δ32基因多态性与A(H1N1)pdm09相关性的Meta分析  

Meta-analysis on association between TNF-α and CCR5Δ32 gene polymorphisms and influenza A(H1N1)pdm09

作　　者：陈涛[1] 肖梦[2] 禇堃 唐晓君[2] 杨静[1] 舒跃龙[1,3] Chen Tao;Xiao Meng;Chu Kun;Tang Xiaojun;Yang Jing;Shu Yuelong(Chinese National Influenza Center,National Institute for Viral Disease Control and Prevention,WHO Collaborating Center for Reference and Research on Influenza,Chinese Center for Disease Control and Prevention,Beijing 102206,China;School of Public Health and Management,Chongqing Medical University,Chongqing 400016,China;School of Public Health(Shenzhen),Sun Yat-sen University,Guangzhou 510275,China)

机构地区：[1]中国疾病预防控制中心病毒病预防控制所国家流感中心,世界卫生组织流感参比和研究合作中心,北京102206 [2]重庆医科大学公共卫生与管理学院,400016 [3]中山大学公共卫生学院(深圳),广州510275

出　　处：《中华流行病学杂志》2020年第11期1909-1914,共6页Chinese Journal of Epidemiology

基　　金：国家传染病重大专项(2018ZX10305409-004-002)。

摘　　要：目的探讨肿瘤坏死因子-α(TNF-α)及CCR5Δ32基因多态性与A(H1N1)pdm09的相关性。方法全面检索PubMed、Cochrane Library、OVID、EBSCO、Web of Science于2019年2月7日及以前发表的相关文献,收集TNF-α及CCR5Δ32基因多态性与A(H1N1)pdm09相关的观察性研究,并按照NOS量表进行严格地质量评价,采用Revman 5.0和Stata 11.0软件进行Meta分析。结果经筛选,共8篇符合排除纳入标准的研究被纳入本次Meta分析,结果显示,TNF-α的基因多态性与A(H1N1)pdm09的发病风险可能具有相关性。rs361525位点携带A等位基因的患者A(H1N1)pdm09是G等位基因的2.25倍(A vs.G:OR=2.25,95%CI:1.09~4.65,P=0.03);rs361525位点AA基因型的携带者感染A(H1N1)pdm09的可能性分别为GG基因型、AG+GG基因型携带者的4.34倍(95%CI:1.65~11.41,P=0.003)、4.38倍(95%CI:1.67~11.48,P=0.003)。rs361525位点的AA+AG基因型可能是人群感染A(H1N1)pdm09的危险因素(rs1800750:AA+AG vs.GG:OR=2.42,95%CI:1.24~4.71,P=0.01)。亚组分析的结果提示,rs361525位点的A等位基因、AA+AG基因型是高加索人种感染A(H1N1)pdm09的危险因素,AA基因型是墨西哥人种感染A(H1N1)pdm09的危险因素(P<0.05)。CCR5的基因多态性与A(H1N1)pdm09的严重程度均无统计学意义(P>0.05)。结论TNF-α基因的rs361525位点具有等位基因A或者AA基因型,或rs1800750位点具有基因型AA+AG的人群可能更易感染A(H1N1)pdm09。Objective To investigate the associations between TNF-αand CCR5Δ32 gene polymorphisms and influenza A(H1N1)pdm09.Methods Studies in PubMed,Cochrane Library,OVID,EBSCO,Web of Science published before February 7,2019 were retrieved comprehensively.Observational studies related to TNF-alpha and CCR5 gene polymorphisms and influenza A(H1N1)pdm09 were collected.A strict quality evaluation was carried out according to NOS scale.Meta-analysis was performed using software Revman 5.0 and Stata 11.0.Results After screening,a total of 8 studies were included in this Meta-analysis.The results showed that TNF-αgene polymorphism rs361525 might be associated with the risk of influenza A(H1N1)pdm09 virus infection(A vs.G:OR=2.25,95%CI:1.09-4.65,P=0.03;AA vs.GG:OR=4.34,95%CI:1.65-11.41,P=0.003;AA vs.AG+GG:OR=4.38,95%CI:1.67-11.48,P=0.003),similar trend also found in rs1800750(AA+AG vs.GG:OR=2.42,95%CI:1.24-4.71,P=0.01).The results of subgroup analysis indicated that A allele and AA+AG genotypes of rs361525 were risk factors for influenza A(H1N1)pdm09 virus infection in Caucasians.AA genotype was a risk factor for influenza A(H1N1)pdm09 virus infection in Mexican(P<0.05).There was no significant difference in the genetic polymorphism of CCR5 and the severity of influenza A(H1N1)pdm09 virus indection(P>0.05).Conclusion People with allele A or genotype AA at rs361525,genotype AA+AG at rs1800750 of TNF-αgene might be more susceptible to influenza A(H1N1)pdm09.

关 键 词：肿瘤坏死因子-Α CCR 基因多态 流行性感冒 

分 类 号：R363[医药卫生—病理学]