μ受体在吗啡成瘾及免疫抑制等疾病中的作用和机制  

Role and mechanism of MOR in morphine addiction,immunosuppression and other diseases

作　　者：卢志鹏 白洁 LU Zhi-peng;BAI Jie(Medical School, Kunming University of Science and Technology, Kunming 650500, China)

机构地区：[1]昆明理工大学医学院,云南昆明650500

出　　处：《中国药理学通报》2020年第12期1636-1639,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81660222,U1202227);云南省高校氧化应激与防御重点实验室(KKPH201960002)。

摘　　要：鸦片是最古老的药物之一,其药理作用大部分是由吗啡所致。吗啡在临床上广泛用于治疗严重急性和慢性疼痛,然而长期使用会导致耐受,甚至成瘾。μ受体(mu-opioid receptor,MOR)在吗啡镇痛、耐受及成瘾中发挥重要作用,此外,MOR表达水平的变化与免疫抑制、肿瘤转移以及认知障碍等疾病有关。该文主要对MOR在吗啡耐受和成瘾以及其他疾患中的作用及机制进行综述。Opium is one of the oldest drugs.Its main pharmacological activity results from morphine.Morphine is widely used to release severe acute and chronic pain in clinic.However,long-term use of morphine will lead to morphine tolerance and even addiction.Mu-opioid receptor(MOR)plays an important role in morphine analgesia,tolerance and addiction.Moreover,changes in the expression of MOR are related to diseases such as immunosuppression,tumor metastasis and cognitive disorders.In this paper,the mechanism of MOR in morphine tolerance,addiction and other diseases are reviewed.

关 键 词：Μ受体 吗啡 耐受 成瘾 免疫抑制 肿瘤 认知障碍 

分 类 号：R-05[医药卫生] R338.64