宫颈小细胞癌的临床病理观察  

Clinicopathological Analysis of Cervical Small Cell Carcinoma

作　　者：梁洁 陈海霞 赵华[1] 杜艳[1] LIANG Jie;CHEN Haixia;ZHAO Hua;DU Yan(Wuxi Maternal and Child Health Hospital,Wuxi,Jiangsu 214002,China)

机构地区：[1]无锡市妇幼保健院,江苏无锡214002

出　　处：《大医生》2020年第16期14-17,共4页Doctor

摘　　要：目的探讨宫颈小细胞癌的临床病理学特点及诊断与鉴别。方法选取无锡市妇幼保健院2008年1月至2020年4月(包括随访期)宫颈小细胞癌病例5例患者的临床资料,对组织病理学和免疫组化进行分析,并复习相关文献。结果患者年龄39~69岁,平均年龄(52.3±1.5)岁,均因不规则阴道出血就诊。组织学形态:肿瘤以巢团状、器官样、片块状结构混合为主,肿瘤细胞呈短梭形,核浆比高,核深染,核仁明显,核分裂多见,胞浆量少,嗜伊红,肿瘤细胞坏死、挤压明显。免疫表型:P16弥漫强阳性,神经内分泌标记物CD56均为阳性,神经元特异性烯醇化酶(NSE)、突触素(Synaptophysin,SYN)、嗜铬素A(Chromogranin A,CgA)、肺磷癌(TTF-1)不同程度阳性表达,上皮标记EMA阳性,Ki-67增殖指数均50%以上。结论宫颈小细胞癌是高度恶性的神经内分泌肿瘤,侵袭性强、预后差。依据组织学形态和免疫组化相结合可明确诊断。Objective To investigate the clinicopathological and immunohistochemical features,diagnonsis and differential diagnonsis of small cell carcinoma of cervix(SCCC).Methods Clinical data of 5 patients with small cell carcinoma of the cervix in Wuxi Maternal and Child Health Hospital from January 2008 to April 2020 were collected,histopathology and immunohistochemistry were analyzed,and relevant literature was reviewed.Results The age of the patients ranged from 39 to 69 years,the average age was(52.3±1.5)years.Irregular vagina bleeding was the major clinical manifestation.Histologically,the neoplastic cells appeared hyperchromatic nuclei and scant cytoplasm.Numerous mitotic figures and extensive necrosis were also comman findings.The immunohistochemical results showed the tumor cells were positive for P16,CD56;and variable positive for NSE,SYN,CgA,TTF-1.Ki-67 index exceeded 50%.Conclusion SCCC is a rare and highly malignant neuroendocrine tumor.Histological features and immunohistological staining may be helpful in diagnosis of SCCC.

关 键 词：小细胞癌 免疫组化 诊断和鉴别诊断 

分 类 号：R73[医药卫生—肿瘤]