结直肠浸润性微乳头状癌临床病理学特征及免疫组化研究  

Clinicopathological Features and Immunohistochemical Study of Infiltrating Micropapillary Carcinoma of Colorectal

作　　者：吴国标 刘自光 陈坚平 申可 Wu Guobiao(Shunde Hospital of Southern Medical University/The First People's Hospital of Shunde District,Foshan Guangdong 528000)

机构地区：[1]南方医科大学顺德医院/佛山市顺德区第一人民医院,广东佛山528000

出　　处：《黑龙江医药》2020年第6期1244-1247,共4页Heilongjiang Medicine journal

基　　金：佛山市卫生和计生局医学科研(项目编号:20180338)

摘　　要：目的:探讨结直肠浸润性微乳头状癌临床病理学特征及免疫组化。方法:研究对象选取我院2010年1月至2014年12月期间收治的结直肠腺癌患者300例,根据组织病理学结果分为IMPC(研究组26例)和普通腺癌(对照组274例)。所有患者均经手术切除肿瘤,将所切除的肿瘤标本进行HE染色与免疫组织化学EnVision法染色,观察其临床病理学特征与免疫组化表型。分析IMPC在结直肠腺癌中的检出率;分析不同IMPC成分比例与淋巴结转移率、血管侵犯、神经侵犯的相关性;比较两组患者的临床病理学特征及免疫组化表型。结果:IMPC在结直肠腺癌中的检出率为8.67%(26例),其中普通腺癌的检出率为91.33%(274例);不同IMPC成分比例与淋巴结转移率、血管侵犯、神经侵犯比较无统计学意义(P>0.05),随IMPC成分比例升高淋巴结转移率、血管侵犯、神经侵犯均呈升高趋势;两组患者的性别、平均年龄、肿块部位、组织学类型比较均无统计学意义(P>0.05),两组患者的浸润深度、淋巴结转移、血管侵犯、神经侵犯远处转移均明显高于对照组(P<0.05);研究组的EMA、CD10与E-cadheri比较均有统计学意义(P<0.05)结论:IMPC具有较高的恶性程度及侵袭性,通过观察免疫组化表型并结合病理学特征,可用于评估患者预后。Objective:To investigate the Clinicopathological Features and immunohistochemistry of colorectal invasive micropapillary carcinoma.Methods:300 patients with colorectal adenocarcinoma admitted to our hospital from January 2010 to December 2014 were selected and divided into IMPC(study group 26 cases)and ordinary adenocarcinoma(control group 274 cases)according to the histopathological results.All patients underwent surgical resection of the tumor,and the tumor specimens were stained with HE staining and Immunohistochemical En Vision staining to observe their Clinicopathological Features and Immunohistochemical phenotypes.The detection rate of IMPC in colorectal adenocarcinoma was analyzed.The correlation between the proportion of different IMPC components and lymph node metastasis rate,vascular invasion and nerve invasion was analyzed.The Clinicopathological Features and Immunohistochemical phenotypes of the two groups were compared.Results:The detection rate of IMPC in colonic adenocarcinoma was 8.67%(26 cases),among which the detection rate of ordinary adenocarcinoma was 91.33%(274 cases).There was no statistically significant difference between the proportion of different IMPC components and lymph node metastasis rate,vascular invasion and nerve invasion(P>0.05).The proportion of IMPC components increased with the increase of lymph node metastasis rate,vascular invasion and nerve invasion.Two groups of patients'average age,gender,tumor type,histological type detection is no statistical significance(P>0.05),two groups of infiltration depth,lymph node metastasis in patients with positive number,vascular invasion and nerve invasion,and distant metastasis were significantly higher than that of control group(P<0.05);The EMA,CD10 and E-Cadheri in the study group were statistically significant(P<0.05).Conclusion:IMPC has a high degree of malignancy and invasiveness,and can be used to evaluate the prognosis of patients by observing the Immunohistochemical phenotype combined with pathological characteristics.

关 键 词：结直肠癌 浸润性微乳头状癌 临床病理学特征 免疫组化 

分 类 号：R735.3[医药卫生—肿瘤]