3-(4-氟-苯基)-5-异丙基-2-苯基-吡咯-1-羧酸苯基酰胺的合成  

SYNTHESIS OF 3-(4-FLUORO-PHENYL)-5-ISOPROPYL-2-PHENYL-PYRROLE-1-CARBOXYLICACID PHENYLAMIDE

作　　者：匡仁云[1] 郭瑾[1] 谢宝星 KUANG Ren-yun;GUO Jing;XIE Bao-xing(School of Chemistry and Chemical Engineering,Jinggangshan University,Ji'an,Jiangxi 343009,China)

机构地区：[1]井冈山大学化学化工学院,江西吉安343009

出　　处：《井冈山大学学报（自然科学版）》2020年第6期15-17,共3页Journal of Jinggangshan University (Natural Science)

基　　金：国家自然科学基金项目(21563015)。

摘　　要：在强碱催化下,甲基异丙酮和4-氟苯甲醛通过羟醛缩合反应得到α,β-不饱和酮2,然后与苯甲醛生成1,4-二酮化合物,将其与醋酸铵在醋酸催化下一锅法得到吡咯化合物,最后在叔丁基锂强碱作用下,与苯基异氰酸酯反应得到目标产物吡咯羧酸苯基酰胺类化合物。α,β-unsaturated ketone is synthesized by aldol reaction of 4-fluorobenzaldehyde and methyl isopropyl ketone in presence of 15%KOH solution,then it reacts with benzaldehyde again for generating 1,4-diketones compound,which reacts with NH4OAc under AcOH catalysis by one-pot synthesis and pyrrole compound is obtained.And finally,under the catalytic action of a strong base of tert-butyllithium,pyrrole compound react with isocyanato-benzene for the target product of phenylamide compounds of pyrrolidine carboxylate.

关 键 词：羟醛缩合 吡咯衍生物 一锅法 合成 

分 类 号：O626.25[理学—有机化学]