黏附性侵袭性大肠杆菌的致病机制及其在克罗恩病中的作用  

Pathogenic mechanism of adhesion-induced invasive Escherichia coli and its role in Crohn′s disease

作　　者：许奕晗 郭振 朱维铭 Xu Yihan;Guo Zhen;Zhu Weiming(Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,China)

机构地区：[1]南京大学医学院附属金陵医院(东部战区总医院)普通外科炎症性肠病治疗中心,南京210002

出　　处：《中华炎性肠病杂志（中英文）》2020年第4期333-336,共4页Chinese Journal of Inflammatory Bowel Diseases

基　　金：国家自然科学基金青年项目(81500429);南京市科技计划项目(201715008)。

摘　　要：肠道微生物群失衡在克罗恩病(CD)发病中扮演着重要角色,尚未发现CD的单一致病微生物,一种特异性定植于CD患者末端回肠黏膜并能侵入肠上皮细胞和巨噬细胞的黏附性侵袭性大肠杆菌被认为与CD的发病密切相关。对黏附性侵袭性大肠杆菌特殊的生物学特性的深入研究可能有助于进一步了解CD的发病机制。The imbalance of intestinal microbiota plays an important role in the pathogenesis of Crohn′s disease(CD).Although monoclonal microorganism associated with CD has not been discovered yet,it has recently been reported that adherent invasive Escherichia coli has a close relationship with the pathogenesis of CD.It is helpful to understand the mechanism of CD by exploring the adherent invasive Escherichia coli.

关 键 词：克罗恩病 肠道微生态 黏附性侵袭性大肠杆菌 

分 类 号：R574[医药卫生—消化系统]