骨形态发生蛋白异源二聚体诱导成骨的研究新进展  

New progress in osteogenesis induced by heterodimer of bone morphogenetic protein

作　　者：周健 涂业颖 赵子慕 黄必行 金佳杨 林海燕[1,2] ZHOU Jian;TU Yeying;ZHAO Zimu;HUANG Bixing;JIN Jiayang;LIN Haiyan(School of Stomatology of Zhejiang Chinese Medicine University,Hangzhou Stomatology Hospital,Hangzhou 310000,China)

机构地区：[1]浙江中医药大学口腔医学院,浙江杭州310000 [2]杭州口腔医院平海院区种植中心,浙江杭州310000

出　　处：《口腔医学》2020年第11期1054-1060,共7页Stomatology

基　　金：浙江省基础公益研究计划(LGJ19H140001)。

摘　　要：骨形态发生蛋白异源二聚体较同源二聚体具有更低的使用剂量和更高的诱导成骨能力,因而受到广泛关注。本文介绍了BMP异源二聚体的相关研究,包括种类结构、作用机制和在诱导成骨方面的研究,比较其与BMP同源二聚体的功能差异,并对其前景作出展望。Bone morphogenetic protein heterodimers have received much attention because they have lower dosages and higher osteo⁃genesis⁃inducing ability than homodimers.This article introduces the related research of BMP heterodimers,including species and structure,mechanism of action,and research on osteoinduction,and compares the functional differences between them and BMP ho⁃modimers,and prospects their future.

关 键 词：骨形态发生蛋白 异源二聚体 同源二聚体 诱导成骨 

分 类 号：R780.2[医药卫生—口腔医学]