环状RNA与甲状腺癌关系的研究进展  

Research progress of the relationship between circular RNAs and thyroid cancer

作　　者：陈松 高庆军 赵代伟 CHEN Song;GAO Qingjun;ZHAO Daiwei(Department of Thyroid Surgery,the Affiliated Hospital of Guizhou Medical University,Guiyang 550000,China)

机构地区：[1]贵州医科大学附属医院甲状腺外科,贵州贵阳550000

出　　处：《中国普通外科杂志》2020年第11期1370-1375,共6页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(81860478)。

摘　　要：环状RNA(circRNA)是新近发现的一种内源性非编码RNA,在多种哺乳动物组织或细胞中广泛表达,且与传统线性RNA相比,circRNA为闭环结构,对RNA外切酶和终止子核酸外切酶降解无效,稳定性好,能在血清、尿液、唾液等体液中检测到。大量文献报道circRNA通过circRNA-microRNA(miRNA)-mRNA网络参与生物的胚胎发育及细胞的增殖、分化、凋亡等多种生物学过程,且与肿瘤的发生,侵袭和转移有关。近年研究证实,甲状腺癌组织中存在circRNA的表达失调,表达失调的circRNA通过充当miRNA的“分子海绵”,调节下游靶基因的表达参与甲状腺癌的发生发展。笔者通过收集circRNA的研究进展,对circRNA在甲状腺癌中的表达及其在甲状腺癌发生、发展、转移过程中的作用及其机制进行综述。Circular RNAs(circRNAs)are a class of newly discovered endogenous non-coding RNAs and are widely expressed in various mammalian tissues or cells.Compared to traditional linear RNAs,circRNAs have strong stability due to the closed-loop structures which are resistant to RNA exonuclease and terminator exonuclease mediated degradation,and can be detected in the serum,urine,saliva and other body fluids.A large number of reports have reported that circRNAs participate in various biological processes such as embryonic development of organisms and cell proliferation,differentiation,and apoptosis through the circRNA-microRNA(miRNA)-mRNA network,and are also related to the occurrence,invasion and metastasis of tumors.Recent studies have confirmed that there is dysregulation of circRNA expressions in thyroid cancer tissue.The dysregulated circRNAs participate in the occurrence and development of thyroid cancer by acting as a molecular sponge of miRNAs to regulate the expression of downstream target genes.Here,the authors based on review of the research progress of circRNAs,address the expression of circRNAs in thyroid cancer and their roles and action mechanisms in the occurrence,development and metastasis of thyroid cancer.

关 键 词：甲状腺肿瘤 环状RNAs 微RNAS 综述 

分 类 号：R736.1[医药卫生—肿瘤]