mRNA m^6A甲基化修饰在心血管疾病中的研究进展  

Research progress of mRNA m^6A methylation modification in cardiovascular diseases

作　　者：徐峰张艳达 梁春[1] 吴宗贵[1] Xu Feng;Zhang Yanda;Liang Chun;Wu Zonggui(Department of Cardiology,Changzheng Hospital Second Military Medical University,Shanghai 200003,China)

机构地区：[1]第二军医大学附属长征医院心内科,上海200003

出　　处：《疑难病杂志》2020年第12期1275-1278,1283,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金资助项目(81473445,91539118,81611130092);上海市科学技术委员会优秀学术带头人计划(17XD1405000);上海市医学领军人才计划(LJRC2015-21);上海市中西医临床协作试点项目(ZY2018-2020-FWTX-1102)。

摘　　要：N6-甲基腺苷(m^6A)甲基化是近年来发现的一种哺乳动物信使RNA(mRNA)转录后的一种基因修饰。作为最普遍的表观遗传学机制之一,mRNA m^6A甲基化与肿瘤发生发展高度相关,其在心血管疾病发病中的作用也受到越来越多的重视。文章就mRNA m^6A甲基化在心血管疾病中的研究进展进行综述。N6 methyladenosine(m^6A)methylation is a genetic modification after transcription of a mammalian messenger RNA(mRNA)discovered in recent years.As one of the most common epigenetic mechanisms,mRNA m^6A methylation is highly related to the occurrence and development of tumors,and its role in the pathogenesis of cardiovascular diseases has also received more and more attention.This article reviews the research progress of mRNA m^6A methylation in cardiovascular diseases.

关 键 词：N6-甲基腺苷 心血管疾病 甲基化 心肌肥厚 

分 类 号：R73[医药卫生—肿瘤]