P.g.LPS诱导的miR-19a调控hPDLFs中TLR2及BSP的表达  

P.g.LPS-induced miR-19a regulates TLR2 and BSP expression in hPDLFs

作　　者：魏蓉 张源 李新月[2] WEI Rong;ZHANG Yuan;LI Xinyue(School of Medicine,Nankai University,300071 Tianjin,China;Department of Periodontics,Tianjin Stomatological Hospital)

机构地区：[1]南开大学医学院,天津300071 [2]天津市口腔医院牙周病科

出　　处：《实用口腔医学杂志》2020年第6期968-969,共2页Journal of Practical Stomatology

摘　　要：运用过表达或抑制miR-19a表达技术转染人牙周膜成纤维细胞(hPDLFs),检测Toll样受体2(TLR2)和骨涎蛋白(BSP)的mRNA及蛋白表达水平。结果表明,过表达miR-19a可以抑制TLR2、上调BSP的表达。Human periondontal ligament fibroblasts(hPDLFs)were transfected by miR-19 a mimics or inhibitor,the mRNA and protein level of Toll-like receptor 2(TLR2)and bone sialoprotein(BSP)were tested by Real-time PCR and Western blot resepecively.The results showed:miR-19 a could inhibit the expression of TLR2 and promote the expression of BSP.

关 键 词：miR-19a 骨涎蛋白(BSP) Toll样受体2(TLR2) 牙龈卟啉单胞菌 脂多糖 

分 类 号：R780.2[医药卫生—口腔医学]