唾液α-突触核蛋白(SNCA)与嗅觉评估在帕金森病早期筛查中的应用研究  

Application Research of Olfactory Assessment and Salivary SNCA in Early Screening of Parkinson’s Disease

作　　者：尚天明 毕开湘 SHANG Tian-ming;BI Kai-xiang(Department of Psychiatry,Baoji Rehabilitation Hospital,Shaanxi Baoji 721000,China)

机构地区：[1]宝鸡市康复医院精神科,陕西宝鸡721000

出　　处：《现代检验医学杂志》2020年第6期95-97,110,共4页Journal of Modern Laboratory Medicine

摘　　要：目的研究唾液α-突触核蛋白(α-synuclein,SNCA)与嗅觉评估在帕金森病(parkinson's disease,PD)早期筛查中的应用。方法选取宝鸡市康复医院2018年2月~2020年2月45例PD患者为观察组,另选取同期45例体检健康者为对照组。比较两组的16种气味识别(SS-16)评分和唾液SNCA。参照改良H-Y临床分级量表,将观察组45例PD患者进一步分为早、中和晚期,分别比较不同分期患者的SS-16评分和唾液SNCA。探究PD病情发展程度与SS-16评分和唾液SNCA的关系,采用受试者工作曲线(ROC)分析SS-16评分与唾液SNCA在PD早筛中的价值。结果观察组的SS-16评分为8.51±3.79分,嗅觉障碍共34例,嗅觉障碍率为75.56%,唾液SNCA为1272.13±38.52pg/ml。对照组的SS-16评分为11.04±3.96分,嗅觉障碍11例,嗅觉障碍率为24.44%,唾液SNCA为1235.16±23.46pg/ml。两组的SS-16评分(t=3.096)、嗅觉障碍率(χ2=23.511)和唾液SNCA(t=5.499)差异均具有统计学意义(均P<0.05)。不同程度PD患者SS-16评分(H=7.456)和唾液SNCA(F=5.130)差异有统计学意义(P<0.05)。经Spearman秩相关分析显示PD病情发展程度与SS-16评分呈显著负相关关系(r=-0.351,P=0.000),其与唾液SNCA呈显著正相关关系(r=0.426,P=0.000)。ROC分析结果显示SS-16评分和唾液SNCA联合检测概率判断早期PD的AUC为0.807,显著高于SS-16评分(P<0.05)和唾液SNCA(P<0.05)单项检测。结论SS-16评分和唾液SNCA与PD发生发展密切相关,联合检测SS-16评分和唾液SNCA有助于PD的早期筛查。Objective To investigate the application ofα-synuclein(SNCA)and olfactory assessment in early screening for Parkinson’s Disease(PD).Methods A total of 45 PD patients in Baoji Rehabilitation Hospital from February 2018 to February 2020 were selected as the observation group,and 45 healthy patients in the same period were selected as the control group.Sixteen odor recognition(SS-16)scores and salivary SNCA were compared between the two groups.Referring to the modified H-Y clinical scale,45 PD patients in the observation group were further divided into early stage,middle stage and late stage,and SS-16 score and salivary SNCA of patients with different stages were compared respectively.Explore the relationship between PD disease progression and SS-16 score and salivary SNCA,and analyzed the value of SS-16 score and salivary SNCA in PD early screening using receiver operating characteristic curve(ROC).Results The SS-16 score of the observation group was 8.51±3.79 points,34 patients had olfaction disorder,the olfaction disorder rate was 75.56%,and the saliar SNCA was 1272.13±38.52 pg/ml.In the control group,the SS-16 score was 11.04±3.96 points,the smell disorder rate was 24.44%in 11 cases,and the salivarial SNCA was 1235.16±23.46 pg/ml.There were statistically significant differences in SS-16 score(t=3.096),olfactory disorder rate(χ2=23.511)and salivary SNCA(t=5.499)between the two groups(all P<0.05).There were statistically significant differences between SS-16(H=7.456)score and salivary SNCA(F=5.130)in PD patients of different degrees(all P<0.05).Spearman rank correlation analysis showed that PD disease progression was negatively correlated with SS-16 score(r=-0.351,P=0.000),and positively correlated with salivarial SNCA(r=0.426,P=0.000).The results of ROC analysis showed that the AUC of SS-16 score and saliva SNCA combined detection probability to judge early PD was 0.807,which was significantly higher than SS-16 score(P<0.05)and saliva SNCA(P<0.05).Conclusion SS-16 score and salivary SNCA were closely rela

关 键 词：嗅觉评估 唾液α-突触核蛋白 帕金森病 早期筛查 

分 类 号：R744.6[医药卫生—神经病学与精神病学] R446.112[医药卫生—临床医学]