S-100B蛋白浓度与食管癌患者术后认知障碍的相关性  

Correlation between S-100B Protein Concentration and Postoperative Cognitive Impairment in Patients with Esophageal Cancer

作　　者：张霞[1] 许柳香 郭昌莹[1] ZHANG Xia;XU Liuxiang;GUO Changying(Jiangxi Cancer Hospital,Nanchang,330029)

机构地区：[1]江西省肿瘤医院,330029 [2]万安县县人民医院,343800

出　　处：《实用癌症杂志》2020年第12期1980-1982,共3页The Practical Journal of Cancer

摘　　要：目的探讨S-100B蛋白浓度与食管癌患者术后认知障碍的相关性。方法选取40例接受食管癌根治术治疗的40例患者为研究对象,术后采用简易认知状态评价量表(MMSE)对所有患者的认知功能进行评估,依据评估结果,未发生认知障碍患者20例为对照组,术后认知障碍患者20例为实验组。所有患者于术前1天、术后1天、术后3天、术后7天测定血清S-100B蛋白水平,分析血清S-100B蛋白浓度变化及其与认知障碍发生的关系。结果术前,2组血清S-100B蛋白浓度对比,差异无统计学意义(P>0.05);术后1天、术后3天,观察组血清S-100B蛋白浓度高于对照组,差异有统计学意义(P<0.05)。不同程度认知功能障碍患者MMSE量表评分及血清S-100B蛋白浓度对比,差异均有统计学意义(P<0.05);经Pearson相关性分析显示,MMSE评分与血清S-100B蛋白浓度呈负相关性(P<0.05)。结论食管癌患者术后认知功能障碍的发生与其血清S-100B蛋白水平有关,S-100B蛋白可作为食管癌患者术后认知障碍的筛查生化指标。Objective To investigate the correlation between S-100B protein concentration and postoperative cognitive impairment in patients with esophageal cancer.Methods 40 patients with esophageal cancer undergoing radical resection were selected as the research object.The cognitive function of all patients was evaluated by MMSE.According to the evaluation results,20 patients without cognitive impairment were selected as the control group,and 20 patients with postoperative cognitive impairment were selected as the experimental group.Serum S-100B protein levels were measured at 1 day before operation,1 day after operation,3 days after operation and 7 days after operation,and the relationship between serum S-100B protein concentration and cognitive impairment was analyzed.Results Before operation,there was no significant difference in serum S-100B protein concentration between the two groups(P>0.05);the serum S-100B protein concentration in the observation group was higher than that in the control group at 1 day,3 days after operation,and the difference was statistically significant(P<0.05);there were significant differences between MMSE score and serum S-100B protein concentration in patients with different degrees of cognitive impairment(P<0.05)Pearson correlation analysis showed that MMSE score was negatively correlated with serum S-100B protein concentration(P<0.05).Conclusion The occurrence of postoperative cognitive dysfunction in patients with esophageal cancer is related to the level of serum S-100B protein.S-100B protein can be used as a biochemical index for screening postoperative cognitive impairment in patients with esophageal cancer.

关 键 词：食管癌 认知功能障碍 血清S-100B 

分 类 号：R735.1[医药卫生—肿瘤]