无创正压通气对肺癌重症呼吸衰竭的临床疗效及对患者生存质量的影响  

Clinical Efficacy and Influence on Quality of Life of Noninvasive Ventilation in the Treatment of Advanced Lung Cancer Patients with Severe Respiratory Failure

作　　者：曾军[1] 周夏飞[1] 李万成[1] ZENG Jun;ZHOU Xiafei;LI Wancheng(First Affiliated Hospital of Chengdu Medical College,Chengdu,610500)

机构地区：[1]成都医学院第一附属医院,610500

出　　处：《实用癌症杂志》2020年第12期2001-2004,共4页The Practical Journal of Cancer

基　　金：四川省医学科研青年创新课题项目(编号:Q17025)。

摘　　要：目的探讨肺癌重症呼吸衰竭应用无创正压通气的临床疗效及对患者生存质量的影响。方法选取100例老年肺癌重症呼吸衰竭患者,按照随机数字表法分为正压通气组(n=50)和对照组(n=50),对照组患者仅接受常规治疗,正压通气组患者在此基础上经鼻罩双水平无创正压通气,观察记录两组患者治疗后2 h、24 h血气分析值,以及通气治疗14天后的临床疗效,随访30 d、180 d,记录患者的一般状况改善情况,对数据进行统计学比较。结果通气组与对照组患者治疗前pH、动脉血二氧化碳分压(PaCO2)、血氧分压(PaO2)无统计学差异(P<0.05),治疗后2h,通气组各项指标较治疗前明显改善,差异具有统计学意义(P<0.05),对照组各项指标未见明显改善,无统计学差异(P>0.05)。治疗后24 h,两组患者各项指标均较前有所好转,但通气组各项指标改善情况均明显优于对照组,差异有统计学意义(P<0.05)。通气治疗14 d的临床疗效以及随访30 d、180 d的一般状况改善情况通气组均优于对照组,差异有统计学意义(P<0.05)。结论对肺癌重症呼吸衰竭的患者应用无创正压通气治疗的临床疗效显著,使患者的生活状况明显改善,生存质量明显提高,值得进一步的临床研究。Objective To analyze the clinical value of noninvasive positive pressure ventilation in advanced lung cancer patients with severe respiratory failure and its impact on patient’s quality of life.Methods 100 elderly advanced lung cancer patients with severe lung cancer and severe respiratory failure were randomly divided into positive pressure ventilation group(n=50)and the control group(n=50)according to the random number table method.The control group only accepted the conventional treatment,patients in the positive pressure ventilation group underwent bi-level non-invasive positive pressure ventilation on the basis of the conventional treatment.The blood gas analysis values of the 2 groups were observed at 2h and 24h after the treatment,and the clinical efficacy after 14 days of ventilation treatment was observed.The follow-up period was 30 days,180 days,the general condition improvement of the patient was recorded,and the data were statistically compared.Results There was no significant difference in pre-treatment pH,arterial blood carbon dioxide partial pressure(PaCO2)and blood oxygen partial pressure(PaO2)between the ventilation group and the control group(P>0.05).After 2 hours of treatment,the indexes of the ventilation group were significantly better than those before treatment.The difference was statistically significant(P<0.05).There was no significant improvement in the control group,and there was no statistical difference(P>0.05).At 24 hours after treatment,the indexes of the 2 groups were better than before,but the improvement of the indexes in the ventilation group was significantly better than that of the control group,and the difference was statistically significant(P<0.05).The clinical efficacy of ventilation treatment for 14 days and the improvement of general condition at 30 days and 180 days were better than the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical efficacy of noninvasive positive pressure ventilation in lung cancer patients with severe

关 键 词：肺肿瘤 无创正压通气 重症呼吸衰竭 临床疗效 生存质量 

分 类 号：R734.2[医药卫生—肿瘤]