脂质组学在中药研究中的应用  

Application of lipidomics on research of traditional Chinese medicine

作　　者：吴丹[1] 孟永海[1] 杨炳友[1] 孙延平[1] 王秋红 匡海学[1] WU Dan;MENG Yong-hai;YANG Bing-you;SUN Yan-ping;WANG Qiu-hong;KUANG Hai-xue(Key Laboratory of Basis and Application Research of North Medicine,Ministry of Education,Heilongjiang University of Chinese Medicine,Harbin 150040,China;School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China)

机构地区：[1]黑龙江中医药大学教育部北药基础与应用研究重点实验室,黑龙江哈尔滨150040 [2]广东药科大学中药学院,广东广州510006

出　　处：《中草药》2020年第21期5405-5413,共9页Chinese Traditional and Herbal Drugs

基　　金：国家重点基础研究发展计划(“973”计划)项目(2013CB531801)。

摘　　要：脂质组学是对生物体中脂质的种类、功能和代谢途径进行系统性研究的一门新兴学科,通过比较不同生理或病理状态下脂质代谢网络的变化,发现疾病或药物的生物标志物和分子机制。脂质组学作为系统生物学的重要组成部分,与中医药的整体观及系统理论相契合,是促进中医药现代化研究的有力工具。主要对脂质组学技术进行简述,总结近年来脂质组学技术在中药药效、作用机制和毒性研究中的应用概况,并结合其他学科在中药药性理论和中药质量控制研究中的应用成果,为拓展脂质组学在中药研究中的应用思路,推动中医药传统理论与现代科学技术的有机融合提供参考。Lipidomics is a newly emerged discipline that systematically studies the types,functions and metabolic pathways of lipids in organisms,which can identify biomarkers and molecular mechanisms of diseases or drugs by analyzing changes in lipid metabolism networks from different physiological or pathological states.As an important component of systems biology,lipidomics has the research mentality which is similar to the overall concept as well as the system theory of traditional Chinese medicine(TCM).Therefore,lipidomics becomes a powerful tool to promote the modernization of TCM.Lipidomics technology is briefly described in this paper,and the application of lipidomics technology on research of TCM including pharmacodynamics,action mechanism and toxicity are summed up,and at the same time the experience of other disciplines in the research of Chinese materia medica property theory and quality control of TCM are combined to expand the application ideas of lipidomics in TCM research,as well as provide references for the organic integration between TCM theory and modern technology.

关 键 词：脂质组学 中药研究 中医药现代化 中药药性理论 中药质量控制 

分 类 号：R285[医药卫生—中药学]