可乐定透皮贴片治疗自闭症谱系障碍儿童行为问题的临床疗效分析  

Clinical analysis of clonidine transdermal patch in treatment of behavior problems in children with autism spectrum disorder

作　　者：王敏建 周雪 蒋国庆[1] WANG Minjian;ZHOU Xue;JIANG Guoqing(Chongqing Mental and Health Center,Chongqing 401147,China)

机构地区：[1]重庆市精神卫生中心,401147

出　　处：《重庆医学》2020年第23期3916-3918,3922,共4页Chongqing medicine

基　　金：重庆市科卫联合医学科研项目(2019MSXM083);重庆市精神卫生中心院级项目(2018-yjkt-01)。

摘　　要：目的探讨可乐定透皮贴片治疗自闭症谱系障碍(ASD)患儿行为问题的临床疗效和安全性。方法42例ASD患儿于治疗前、治疗后4周和治疗后8周采用病情严重程度分量表(SI)、孤独症治疗评估量表(ATEC)和CONNER父母用症状问卷(PSQ)进行临床疗效评定;采用副反应量表(TESS)进行药物副作用评定;于治疗前和治疗后8周进行血尿常规、肝肾功能检查,于治疗前、治疗后4周和治疗后8周行心电图检查,治疗后每周监测血压。结果SI、ATEC总分和行为因子、PSQ多动和多动-冲动因子在治疗前、治疗后4周和治疗后8周比较差异有统计学意义(P<0.05)。治疗后副作用轻微,主要为镇静、皮肤局部皮疹等。每周监测血压均无临床意义的降低。心电图、脑电图、血常规、尿常规和肝肾功能均无临床意义的异常。结论可乐定透皮贴片对ASD患儿行为问题改善疗效好,安全性高,使用方便。Objective To explore the efficacy and safety of clonidine transdermal patch in the treatment of behavioral problems in children with autism spectrum disorder(ASD).Methods A total of 42 cases of ASD were assessed by severity scale(SI),Autism Treatment Assessment Scale(ATEC)and CONNER parents questionnaire(PSQ)before treatment and at 4,8 weeks after treatment.Side effects were assessed using Treatment Emergent Symptom Scale(TESS).Blood and urine routine test,liver and kidney function test were carried out before treatment and 8 weeks after treatment.ECG examination was carried out before treatment and 4,8 weeks after treatment.Blood pressure was monitored weekly.Results There were significant differences in scores of SI,ATEC score and behavioral factors,PSQ hyperactivity and hyperactivity-impulse factors before treatment and 4,8 weeks after treatment(P<0.05).After treatment,the side effects were mild,including sedation and local skin rash.Weekly monitoring of blood pressure showed no clinically significant reduction.Electrocardiogram,electroencephalogram,blood routine examination,urine routine examination,liver and kidney function showed no clinical significance.Conclusion Clonidine transdermal patch has good efficacy in improving behavior problems of ASD with high safety and convenient use.

关 键 词：孤独症谱系障碍 可乐定 发育行为问题 治疗结果 安全性 

分 类 号：R749.94[医药卫生—神经病学与精神病学]