血清巨泌乳素水平检测在抗精神病药致高泌乳素血症中的意义  

Significance of macroprolactin detection in hyperprolactinemia induced by antipsychotics

作　　者：王振华 陈海支[1] 金海英 费小聪[1] 李建华[1] 雷礼磊 刘建君[1] WANG Zhen-hua;CHEN Hai-zhi;JIN Hai-ying;FEI Xiao-cong;LI Jian-hua;LEI Li-lei;LIU Jian-jun(the Third People's Hospital of Huzhou,Huzhou 313000,China)

机构地区：[1]浙江省湖州市第三人民医院,313000

出　　处：《临床精神医学杂志》2020年第6期398-400,共3页Journal of Clinical Psychiatry

基　　金：湖州市科技局一般计划项目(2017GYB05)。

摘　　要：目的:探讨血清巨泌乳素(MPRL)水平检测在抗精神病药致高泌乳素血症(HPRL)中的临床意义。方法:于2016年4月至2018年4月共收集精神分裂症患者133例,对其进行利培酮或氨磺必利单药治疗6周,于治疗前、治疗2周、治疗4周和治疗6周后检测总泌乳素(T-PRL)和MPRL水平。结果:经治疗2周后有75.09%(100/133)的患者达到HPRL诊断标准,其中43%(43/100)符合MPRL血症诊断标准;且血清MPRL与T-PRL水平呈正相关。结论:利培酮、氨磺必利所致HPRL患者中有近一半实为MPRL血症。MPRL检测值得引起临床关注。Objective:To investigate the situation and clinical significance of macroprolactin in patients with hyperprolactinemia induced by antipsychotics.Method:133 patients with schizophrenia were treated with risperidone or amisulpride alone for 6 weeks from April 2016 to April 2018.The levels of T-PRL and MPRL were measured before the treatment,and after 2,4,6 weeks of the treatment.Results:After 2 weeks of the treatment,75.09%(100/133)of the patients met the diagnostic criteria of hyperprolactinemia,the incidence of macroprolactinemia was 43%(43/100).The MPRL level was positively correlated with T-PRL level.Conclusion:Nearly half of the patients with hyperprolactinemia caused by risperidone and amisulpride are macroprolactinemia.The detection of macroprolactin should be paid attention in clinical practice.

关 键 词：抗精神病药 巨泌乳素 泌乳素 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]