鳞状细胞癌抗原及肝细胞生长因子受体检测对宫颈癌淋巴结转移和预后的评估价值  

Squamous cell carcinoma-antigen and c-met detection in evaluating lymph node metastasis of cervical cancer and prognosis

作　　者：孙亚妮 雷静[1] 马文娟 SUN Yani;LEI Jing;MAWenjuan(Department of Obstetrics and Gynecology,Fourth Hospital of Xi’an,Xi’an 710004,Shaanxi,China)

机构地区：[1]西安市第四医院妇产科,西安710004

出　　处：《癌症进展》2020年第22期2323-2326,共4页Oncology Progress

摘　　要：目的鳞状细胞癌抗原(SCC-Ag)及肝细胞生长因子受体(HGFR,也称c-met)检测对宫颈癌淋巴结转移和预后的评估价值。方法检测114例宫颈癌患者血清SCC-Ag水平及宫颈癌组织c-met的表达情况,及其与患者临床特征的关系。对患者进行为期2年的随访,观察宫颈癌患者的预后情况,宫颈癌患者死亡及淋巴结转移的影响因素采用多元Logistic回归分析。结果临床分期为Ⅱa+Ⅱb期、分化程度为低分化、浸润深度﹥50%且有淋巴结转移的宫颈癌患者的血清SCC-Ag、c-met阳性表达率均高于临床分期为Ⅰ期、分化程度为中高分化、浸润深度≤50%和无淋巴结转移的患者,差异均有统计学意义(P﹤0.05)。术后对患者进行为期2年的随访,死亡18例(17.54%),生存96例(84.21%)。Logistic回归分析结果显示,临床分期为Ⅱa+Ⅱb期、分化程度为低分化、有淋巴结转移、SCC-Ag阳性、c-met阳性均是宫颈癌患者死亡的独立危险因素(P﹤0.05)。结论临床分期为Ⅱa+Ⅱb期、分化程度为低分化、有淋巴结转移、SCC-Ag阳性、c-met阳性是宫颈癌患者死亡的独立危险因素。Objective To analyze the value of squamous cell carcinoma-antigen(SSC-Ag)and hepatocyte growth factor receptor(c-met)detection in evaluating lymph node metastasis of cervical cancer and prognosis.Method Serum SCC-Ag levels and c-met expression in cervical cancer tissues were detected in 114 patients with cervical cancer,and the relationship with clinicopathological characteristics was analyzed.The patients were followed up for 2 years to observe the prognosis of patients with cervical cancer.Multiple logistic regression was used to analyze the independent risk factors for death and lymph node metastasis of patients with cervical cancer.Result The positive rates of serum SCC-Ag and c-met in patients with clinical stage of IIa+IIb,low differentiation,infiltration depth>50%and lymph node metastasis were higher than those of patients with clinical stage I,middle-high differentiation,infiltration depth≤50%,and no lymph node metastasis(P<0.05).18 cases died(17.54%)and 96 cases survived(84.21%)after 2 years follow-up.Logistic regression analysis showed that the clinical stage of IIa+IIb,low differentiation,lymph node metastasis,positive SCC-Ag,and positive c-met were independent risk factors for death in patients with cervical cancer(P<0.05).Conclusion The clinical stage of IIa+IIb,low differentiation,lymph node metastasis,positive SCC-Ag,and positive c-met are independent risk factors for the death of patients with cervical cancer.

关 键 词：宫颈癌 鳞状细胞癌抗原 肝细胞生长因子受体 预后 

分 类 号：R737.33[医药卫生—肿瘤]