溃疡性结肠炎患者血清25-羟维生素D3与病情严重程度的相关性分析  

Correlation Analysis between Serum 25-hydroxyvitamin D and Severity of the Patients with Ulcerative Colitis

作　　者：欧阳小予[1] 陈永梅 孙娟[1] OUYANG Xiaoyu;CHEN Yongmei;SUN Juan(Department of Gastroenterology,the Second Hospital of Sanming City,Yongan City,Fujian Province 366000)

机构地区：[1]三明市第二医院消化内科,福建省永安市366000

出　　处：《医学理论与实践》2020年第24期4056-4058,4064,共4页The Journal of Medical Theory and Practice

摘　　要：目的:探讨溃疡性结肠炎(UC)患者血清25-羟维生素D3水平变化,分析其水平与UC病情严重程度的相关性。方法:纳入临床确诊的UC患者78例为观察组,同期门诊健康体检者40例为对照组,对比两组血白蛋白(ALB)、甘油三酯(TG)、低密度脂蛋白(LDLC)、总胆固醇(TC)、白细胞(WBC)、中性粒细胞/淋巴细胞比值(NLR)、血红蛋白(Hb)、血小板(PLT)、单核细胞/淋巴细胞比值(MLR)、血小板/淋巴细胞比值(PLR)、血沉(ESR)、C反应蛋白(CRP)、25-羟维生素D3的差异。根据改良Mayo评分系统将UC分成轻度活动组(3分≤Mayo评分≤5分)、中度活动组(6分≤Mayo评分≤10分)、重度活动组(11分≤Mayo评分≤12分),根据病变范围将UC分成E1组(局限于直肠)、E2组(累及左半结肠)、E3组(广泛病变),对比各组25-羟维生素D3水平,分析25-羟维生素D3水平与Mayo评分、NLR、MLR、PLR的相关性。结果:(1)观察组ALB、TG、TC、LDLC、Hb、25-羟维生素D3均低于对照组,而WBC、PLT、CRP、ESR、NLR、MLR、PLR均明显高于对照组(均P<0.01)。(2)随着UC病情严重程度及病变部位的增加,血清25-羟维生素D3均逐渐降低,差异有统计学意义(均P<0.01)。(3)Pearson相关分析显示:25-羟维生素D3与Mayo内镜评分、NLR、MLR、PLR、CRP、ESR均呈明显负相关(均P<0.05或P<0.01)。结论:UC患者血清25-羟维生素D3降低,其水平与UC病情严重程度、病变部位呈明显负相关。Objective:To investigate the levels of serum 25-hydroxyvitamin D3 in patients with ulcerative colitis,and analyze the correlation between serum 25-hydroxyvitamin D3 and severity of the patients with ulcerative colitis.Methods:A total of 78 patients diagnosed with ulcerative colitis in our hospital were selected for the observation group,another 40 healthy subjects were selected for the control group.The differences in albumin(ALB),triglycerides(TG),low density lipoprotein(LDLC),total cholesterol(TC),white blood cell(WBC),hemoglobin(Hb),platelets(PLT),neutrophil to lymphocyte ratio(NLR),monocyte to lymphocyte ratio(MLR),platelet to lymphocyte ratio(PLR),blood sedimentation(ESR),C-reactive protein(CRP),25-hydroxyvitamin D3 were compared among the two groups.All ulcerative colitis patients were divided into the mild disease activity group(3≤Mayo score≤5),moderate disease activity group(6≤Mayo score≤10)and severe disease activity group(11≤Mayo score≤12)and divided into E1 group(confined to he rectum),E2 group and(distal colon including the rectum),E3 group(the wide range of colon)according to the lesion site.Contrast the differences of the serum 25-hydroxyvitamin D3 among all groups,and analyze the correlation between serum 25-hydroxyvitamin D3 and the Mayo score,NLR,MLR,PLR in patients with ulcerative colitis.Results:(1)All the levels of ALB,TG,TC,LDLC,Hb and 25-hydroxyvitamin D3 in the observation group were significantly lower than those in the control group,but the levels of WBC,PLT,CRP,ESR,NLR,MLR,PLR in the observation group were significantly higher than those in the control group(all P<0.01).(2)As the severity of disease activity and lesion site increases,the levels of serum 25-hydroxyvitamin D3 gradually decreased(all P<0.01).(3)Pearson Linear correlation analysis show that serum 25-hydroxyvitamin D3 in the patients with ulcerative colitis were negatively correlated with Mayo score,NLR,MLR,PLR,CRP,ESR(all P<0.01 or P<0.05).Conclusion:Serum 25-hydroxyvitamin D3 in patients with ulcerative colitis

关 键 词：溃疡性结肠炎 25-羟维生素D3 疾病严重程度 Mayo评分 相关性 

分 类 号：R574.62[医药卫生—消化系统]