高海拔头痛发生与其生理、生化指标变化的相关性研究  

Study on physiological and biochemical factors associated with high altitude headache

作　　者：刘小书 LIU Xiaoshu(Department of Clinical Laboratory,Wenjiang Maternal and Child Health Care Hospital,Chengdu,Sichuan 611130,China)

机构地区：[1]成都市温江区妇幼保健院检验科,四川成都611130

出　　处：《国际检验医学杂志》2020年第24期3011-3014,3019,共5页International Journal of Laboratory Medicine

摘　　要：目的探讨分析高海拔头痛(HAH)发生与生理、生化指标变化的相关性。方法选取2018年1月至2019年8月由低海拔地区进入高海拔地区的健康志愿者44例,按是否发生HAH分为HAH+组(33例)与HAH-组(11例),对比两组生理、生化指标变化,以与发生HAH有关的因素为变量组进行单因素及多因素Logistic回归分析。结果本研究HAH的发生率为75%。在低海拔地区时,两组除血尿素氮(BUN)外,其余指标比较,差异均无统计学意义(P>0.05)。进入高海拔地区后,HAH+组血氧饱和度(SpO2)、收缩压(SBP)、BUN均较HAH-组更低,差异有统计学意义(P<0.05);而HAH+组的心率(HR)明显高于HAH-组,差异有统计学意义(P<0.05);其余指标差异无统计学意义(P>0.05)。多元Logistic回归分析表明,对于低海拔地区,BUN与HAH相关;对于高海拔地区,SpO2、HR、BUN与HAH相关。结论生理、生化指标HR、SpO2、BUN在HAH人群中存在明显变化,可作为HAH预防、治疗的重要观察指标,具有较高的临床诊断及指导治疗价值。Objective To explore the physiological and biochemical factors related to high altitude headache(HAH).Methods From January 2018 to August 2019,a total of 44 healthy volunteers from low altitude to high altitude areas were selected.According to the occurrence of HAH,they were divided into HAH+group(33 cases)and HAH-group(11 cases).The physiological and biochemical indexes were compared,and univariate and multivariate Logistic regression analysis were performed using the factors related to occurrence of HAH as variables.Results The incidence of HAH was 75%.At low altitude area,except for the blood uree nitrogen(BUN)indicator,there was no significant difference in any indicatora between the two groups(P>0.05).At high altitude area,blood oxgyen saturation(SpO2),systolic pressure(SBP)and BUN were lower in the HAH+group than in the HAH-group,and the differences were statistically significant(P<0.05).The heart rate(HR)in the HAH+group was significantly higher than that in the HAH-group,and the difference was statistically significant(P<0.05),and there was no significant difference in the other indicators(P>0.05).Multivariate Logistic regression revealed that for parameters at low altitude area,BUN was associated with HAH,and for parameters at high altitude area,SpO2,HR and BUN were associated with HAH independently.Conclusion HR,SpO2,and BUN have obvious changes in HAH population,which can be used as important observation indicators for HAH prevention and treatment,and have higher clinical diagnosis and guiding treatment value.

关 键 词：高海拔头痛 生理因素 生化因素 

分 类 号：R747.2[医药卫生—神经病学与精神病学]