宫颈腺癌中抑癌基因甲基化的研究进展  

Research Progress on Tumor Suppressor Genes Methylation in Cervical Adenocarcinoma

作　　者：李铭 王玲[1] 王一男[1] 段雪峰 周顺卿[1] 韩丽英(审校)[1] LI Ming;WANG Ling;WANG Yi-nan;DUAN Xue-feng;ZHOU Shun-qing;HAN Li-ying(Department of Obstetrics and Gynecology,The Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学第二医院妇产科,长春130041

出　　处：《国际妇产科学杂志》2020年第6期611-615,共5页Journal of International Obstetrics and Gynecology

摘　　要：宫颈癌是女性常见癌症之一,在发展中国家发病率更高。随着宫颈癌前筛查的普及,宫颈癌特别是宫颈鳞癌的发病率显著下降,但由于宫颈腺癌并非都伴随人乳头瘤病毒(human papilloma virus,HPV)感染且病变位置深入宫颈管内,现有的筛查手段对宫颈腺癌的诊断效果欠佳。与宫颈鳞癌相比,宫颈腺癌的预后较差。DNA甲基化是基因表观遗传修饰的重要组成部分,可在不改变DNA序列的前提下,改变基因结构,抑制基因表达。抑癌基因的甲基化可使其失活,失去对肿瘤的抑制作用,与肿瘤的发生发展密切相关。总结宫颈腺癌中抑癌基因甲基化的研究进展,以期为宫颈腺癌的早期诊断和治疗提供新的思路。Cervical carcinoma is one of the most common cancers of women,which has a higher incidence in developing countries.With the popularization of the screening in cervical carcinoma,the incidence of cervical carcinoma,especially squamous cell carcinoma has declined.However,because human papilloma virus(HPV)infection does not always accompany cervical adenocarcinoma and the lesion is deep into the cervical canal,the existing screening methods are less effective in the diagnosis of cervical adenocarcinoma.Compared with cervical squamous cell carcinoma,the prognosis of cervical adenocarcinoma is poor.Gene methylation is an important part of epigenetic modification,which can change gene structure and inhibit gene expression without changing DNA sequence.The methylation of tumor suppressor gene can make it inactivated and lose its inhibitory effect on tumor,which is closely related to the occurrence and development of tumor.In this paper,the research progress of gene methylation in cervical adenocarcinoma was reviewed in order to provide new ideas for early diagnosis and treatment of cervical adenocarcinoma.

关 键 词：宫颈肿瘤 腺癌 DNA甲基化 基因 肿瘤抑制 诊断 治疗 

分 类 号：R737.33[医药卫生—肿瘤]