原发性阴道腺癌合并淋巴上皮瘤样癌一例及文献复习  

Primary Vaginal Adenocarcinoma with Lymphoepithelioma-Like Carcinoma:A Case Report and Literature Review

作　　者：陈玉莹 崔满华[1] 刘子玮 贾妍[1] CHEN Yu-ying;CUI Man-hua;LIU Zi-wei;JIA Yan(Department of Obstetrics and Gynecology,The Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学第二医院妇产科,长春130041

出　　处：《国际妇产科学杂志》2020年第6期645-647,F0003,共4页Journal of International Obstetrics and Gynecology

摘　　要：淋巴上皮瘤样癌是伴有显著的淋巴浆细胞浸润的未分化癌,多见于鼻咽部,在女性生殖系统仍属罕见。阴道淋巴上皮瘤样癌是阴道鳞癌亚型之一。原发性阴道腺癌合并淋巴上皮瘤样癌国内外少见报道。本研究报告了1例年轻的原发性阴道癌患者,肿瘤为混合性低分化阴道癌,由腺癌和淋巴上皮瘤样癌组成,镜下见非典型腺体及淋巴细胞和浆细胞大量浸润,免疫组织化学提示:CK(AE1/AE3)(+)。这种罕见的阴道肿瘤在术前和围手术期都很难确诊,虽为未分化癌但伴有大量淋巴细胞浸润,提示此类疾病预后相对较好。本研究通过回顾性分析该患者临床资料,并复习相关文献,总结该疾病临床特点、病理形态和免疫表型,以期提高对本病的认识。Lymphoepithelioma-like carcinoma is defined as a poorly differentiated carcinoma with prominent lymphoplasmacytic infiltrate,which is commonly reported in the nasopharynx and remains a rare condition in gynecology.Lymphoepithelioma-like carcinoma of the vagina is a subtype of squamous cell carcinoma.Primary vaginal adenocarcinoma combined with lymphoepithelioma-like carcinoma has not been reported at home or abroad.We present a case of a young patient with primary vagina cancer and the tumor was a mixed poorly undifferentiated vaginal carcinoma consisting of adenocarcinoma and lymphoepithelioma-like carcinoma.Atypical glands and large infiltration of lymphocytes and plasma cells were seen under the microscope and immunohistochemistry showed CK(AE1/AE3)(+).This rare tumor of the vagina is difficult to diagnose both preoperatively and perioperatively.However,the poorly undifferentiated vaginal carcinoma with massive involvement of lymphoplasmacytic infiltrate indicates that the prognosis is relatively good.In order to improve the understanding of this disease,this study retrospectively analyzed the clinical data of the patient,reviewed relevant literature,and summarized the clinical features,pathological morphology and immunophenotype of this disease.

关 键 词：阴道肿瘤 腺癌 免疫组织化学 淋巴上皮瘤样癌 

分 类 号：R737.34[医药卫生—肿瘤]