茄科植物糖苷生物碱抗肿瘤活性及其构效关系研究进展  

Research progress on antitumor activity and structure-activity relationship of glycoalkaloids from Solanaceae plants

作　　者：吴桐 王建农[1] WU Tong;WANG Jian-nong(Institute of Basic Medical Sciences of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院基础医学研究所,北京100091

出　　处：《天然产物研究与开发》2020年第12期2142-2147,2002,共7页Natural Product Research and Development

基　　金：国家自然科学基金(81872989);北京市自然科学基金(7102137);国家重大新药创制(2009ZX09103-402);北京市科学技术委员会G20工程支撑保障-十病十药研发(Z151100003815026)。

摘　　要：糖苷生物碱是一种广泛存在于茄科植物中的天然产物,因其具有重要的生物活性而受到人们的重视。糖苷生物碱中糖苷配基与糖部分的不同组合使其具有不的化学结构,而化学结构决定了其生物活性,目前研究最多的是其显著的抗肿瘤活性。然而迄今为止,该类化合物的确切抗肿瘤药理机制和其构效关系尚未得到阐明。因此,本文从化学结构、抗肿瘤活性和构效关系三个方面进行综述,为糖苷生物碱抗肿瘤临床应用提供科学依据。Glycoalkaloids are natural products widely found in Solanaceae plants,which have been valued by people for their important biological activities.The different combinations of aglycone and sugar moieties in glycoalkaloids give them different chemical structures which determine their biological activities.The most studied at present is their remarkable antitumor activity.However,the exact antitumor pharmacological mechanism and structure-activity relationship of these compounds have not been elucidated yet up to now.Therefore,we review the chemical structure,antitumor activity and structure-activity relationship of glycoalkaloids in this paper to provide a scientific basis for their antitumor clinical application.

关 键 词：糖苷生物碱 茄科 抗肿瘤 构效关系 作用机制 

分 类 号：R932[医药卫生—生药学]