HDAC6、α-tubulin蛋白表达与喉癌的关系  

RELATIONSHIP BETWEEN HDAC6、α-TUBULIN PROTEIN AND LARYNGEAL CARCINOMA

作　　者：张再兴 魏巍 Zhang Zaixing;Wei Wei(Department of Otorhinolarsngology,Affiliated Hos pilal of North China University of Science and Technology,Tangshan 063000,China)

机构地区：[1]华北理工大学附属医院耳鼻咽喉科,河北省唐山市063000

出　　处：《中国煤炭工业医学杂志》2020年第6期606-610,共5页Chinese Journal of Coal Industry Medicine

基　　金：河北省医学科学研究重点课题计划(编号:20170910)。

摘　　要：目的探讨HDAC6、α-tubulin蛋白表达与喉癌的关系。方法采用免疫组织化学法检测55例喉癌组织及41例声带息肉组织中HDAC6、α-tubulin蛋白的表达,分析HDAC6、α-tubulin蛋白表达与临床病理特征的关系。结果 HDAC6、α-tubulin蛋白在喉癌组织中的阳性表达率分别为78.2%、65.5%,在声带息肉组织中的阳性表达率分别为34.1%、26.8%,HDAC6、α-tubulin在喉癌与声带息肉组织中表达差异均有统计学意义(均P<0.01)。HDAC6、α-tubulin蛋白在Ⅲ、Ⅳ期喉癌组织的阳性表达率分别为95.7%、87.0%,在Ⅰ、Ⅱ期喉癌组织中的阳性表达率分别为65.6%、50.3%,Ⅲ、Ⅳ期喉癌组织与Ⅰ、Ⅱ期喉癌组织中HDAC6、α-tubulin蛋白表达差异均有统计学意义(均P<0.05)。HDAC6蛋白在高中低分化喉癌组织中的阳性表达率分别为50.0%、70.0%及89.5%,α-tubulin蛋白在高中低分化喉癌组织中的阳性表达率分别为31.3%、70.0%及89.5%,HDAC6、α-tubulin在高中低分化喉癌组织中表达差异均有统计学意义(均P<0.05)。结论HDAC6、α-tubulin蛋白在喉癌组织中表达升高,二者可能在喉癌发生发展过程中发挥共同作用。Objective To investigate the expression of HDAC6、α-tubulin protein and its correlation with laryngeal carcinoma(LC).Methods The expression of HDAC6、α-tubulin protein were detected in fifty five cases of LC samples and 41 cases of vocal cord polyp(VCP)tissues by immunohistochemical methods.Then the relationship between the expression of HDAC6、α-tubulin protein in LC and clinical pathological features was analyzed.Results The positive expression rates of HDAC6,α-tubulin in LC were 78.2% and 65.5%.In VCP tissues,the positive expression rates of HDAC6,α-tubslin were 34.1% and 26.8%.The difference of HDAC6 and α-tubulin expression in LC and VCP tissues was statistically significant(P<0.01).The positive expression rates of HDAC6 and α-tubulin were 95.7% and 87.0% in stage Ⅲ,Ⅳ LC,and 65.6% and 50.3% in stage Ⅰ,Ⅱ LC respectively.The difference of HDAC6 and α-tubulin expression between stage Ⅲ,Ⅳ and Ⅰ,Ⅱ was statistically significant(P<0.05).The positive expression rates of HDAC6 protein were 50.0%,70.0% and 89.5% in high,middle and low differentiated laryngeal cancer tissues.The positive expression rates of α-tubulin protein in high,middle and low differentiated LC tissues were 31.3%,70.0% and 89.5%.There were significant differences among high,middle and low differentiated LC tissues(P<0.05).Conclusion The expression of HDAC6,α-tubulin protein increased in LC and it may play a joint role in the occurrence and development of LC.

关 键 词：喉癌 组蛋白去乙酰化酶6 Α-微管蛋白 免疫组织化学 

分 类 号：R739.65[医药卫生—肿瘤]