血清PDGF-D表达水平与老年出血性脑卒中患者颅内血肿扩大的相关性  

The correlation between the expression of PDGF-D in serum and the expansion of intracranial hematoma in elderly patients with hemorrhagic stroke

作　　者：韩非[1] 王颖竹[2] 杨鹏[1] 顾俊怡[3] HAN Fei;WANG Ying-Zhu;YANG Peng(Department of Emergency,the First Hospital Affiliated to Suzhou University,Suzhou 215006,Jiangsu,China)

机构地区：[1]苏州大学附属第一医院急诊科,江苏苏州215006 [2]苏州大学附属第一医院老年科,江苏苏州215006 [3]苏州大学附属第一医院神经外科,江苏苏州215006

出　　处：《中国老年学杂志》2020年第24期5179-5182,共4页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助项目(81701213);第五批姑苏卫生人才培养项目(GSWS2019037)。

摘　　要：目的探究血小板源性生长因子(PDGF)-D在老年出血性脑卒中(HS)患者血清中的表达水平及与颅内血肿扩大的关系。方法189例老年HS患者,根据颅内血肿是否扩大分为血肿扩大组(62例)及血肿未扩大组(127例)。分析比较两组HS患者临床资料;采用酶联免疫吸附试验(ELISA)检测两组HS患者血清PDGF-D、肿瘤坏死因子(TNF)-α水平;比较两组研究对象入院时血肿量(V1)、复查血肿量(V2),计算V2/V1比值;分析血肿扩大患者血清PDGF-D、V2与收缩压、舒张压、格拉斯哥昏迷评分(GCS)、TNF-α关系;以Logistic回归分析颅内血肿扩大的影响因素。结果血肿扩大组收缩压、舒张压、GCS评分、血清PDGF-D、TNF-α水平、V2及V2/V1值均明显高于血肿未扩大组(P<0.05);血肿扩大患者血清PDGF-D水平与GCS评分、TNF-α水平,V2与入院收缩压、GCS评分、TNF-α水平均呈正相关(均P<0.05);收缩压、GCS评分、PDGF-D、TNF-α均为血肿扩大的危险因素(P均<0.05)。结论PDGF-D在血肿扩大的HS患者血清中呈高表达,PDGF-D是影响血肿扩大的危险因素,其可能在HS患者发生血肿扩大的过程中发挥作用。Objective To investigate the expression of platelet-derived growth factor(PDGF)-D in the serum of elderly patients with hemorrhagic stroke(HS)and its relationship with the expansion of intracranial hematoma.Methods 189 elderly patients with HS admitted to hospital from June 2016 to August 2019 were selected,and according to whether the intracranial hematoma expanded,they were divided into hematoma enlargement group(62 cases)and hematoma non-enlargement group(127 cases).The clinical data of HS patients in the two groups were analyzed and compared;the levels of serum PDGF-D and TNF-αwere detected by enzyme-linked immunosorbent assay(ELISA);the volume of hematoma at admission V1 and the volume of hematoma at reexamination V2 were compared between the two groups,and the V2/V1 ratio were calculated.Relationships between PDGF-D,volume of hematoma at reexamination V2 and systolic blood pressure,diastolic blood pressure,Glasgow Coma Score(GCS),TNF-αwere analyzed,and Logistic regression was used to analyze the influencing factors of intracranial hematoma enlargement.Results The systolic blood pressure,diastolic blood pressure,GCS score,serum PDGF-D,TNF-αlevels,volume of hematoma at reexamination V2 and V2/V1 were significantly higher in hematoma enlargement group than those in hematoma non-enlargement group(P<0.05);the level of PDGF-D was positively correlated with GCS score and level of TNF-αin patients with hematoma enlargement(r=0.425,0.397,P<0.05),the volume of hematoma at reexamination V2 was positively correlated with systolic blood pressure at admission,GCS score and TNF-αlevel(r=0.412,0.376,0.528,P<0.05);the systolic blood pressure,GCS score,PDGF-D and TNF-αwere all risk factors for hematoma enlargement(95%CI=1.349~2.214,1.572~2.046,1.339~1.867,1.429~2.358,P<0.05).Conclusions PDGF-D is highly expressed in the serum of HS patients with hematoma enlargement,PDGF-D is a risk factor of hematoma enlargement,which might play a role in the process of hematoma enlargement in HS patients.

关 键 词：血小板源性生长因子-D 出血性脑卒中 血肿扩大 

分 类 号：R743.3[医药卫生—神经病学与精神病学]